{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu IH"],"funding":["National Cancer Institute","NCI NIH HHS","Cancer Prevention and Research Institute of Texas"],"pagination":["168-176"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8370575"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(2)"],"pubmed_abstract":["<h4>Study objectives</h4>The primary aim of the study was to estimate the effect of sleep duration on prospective type 2 diabetes (T2D) risk across demographic characteristics and follow-up periods, and test body mass index (BMI) as a mediator and moderator.<h4>Methods</h4>Data included adults (M<sub>age</sub> = 39.0 ± 12.7 years) born in the United States or Mexico recruited from 2001 to 2012 in a Mexican American cohort study conducted in Houston, TX (n = 15,779). Participants completed self-reported questionnaires at baseline related to health, health behaviors (sleep duration, physical activity, smoking, drinking), and sociocultural factors and were followed up annually.<h4>Results</h4>Cox proportional hazard models estimated hazard ratios (HR) for the effect of sleep duration on T2D diagnosis at follow-up. Of the participants, 10.3% were diagnosed with T2D. Self-reported ≤5 hours of sleep, compared to 7-8 hours, at baseline predicted greater risk for T2D (HR = 1.32, P = .001), yet was no longer significant after adjusting for sociodemographic characteristics and BMI. Notably, those with BMI <25 kg/m<sup>2</sup> reporting ≤5 hours of sleep were at significant risk for T2D at 3 (HR = 4.13, P = .024) and 5-year follow-up (HR = 3.73, P = .008) compared to 7-8 hours. Obesity status accounted for 31.6% and 27.3% of the variance in the association between ≤5 and 6 hours of sleep and increased T2D risk, respectively.<h4>Conclusions</h4>Results highlighted the mediating and moderating role of BMI, and its effect on T2D risk at earlier follow-up among those without obesity. T2D prevention and control for Mexican American adults should consider the role of chronic sleep loss."],"journal":["Sleep health"],"pubmed_title":["Sleep duration and type 2 diabetes risk: A prospective study in a population-based Mexican American cohort."],"pmcid":["PMC8370575"],"funding_grant_id":["P30 CA016672","P20 CA221697","P20 CA221696"],"pubmed_authors":["Heredia N","Balachandran DD","Chang S","Dong Q","Wu IH","Lu Q","McNeill LH"],"additional_accession":[]},"is_claimable":false,"name":"Sleep duration and type 2 diabetes risk: A prospective study in a population-based Mexican American cohort.","description":"<h4>Study objectives</h4>The primary aim of the study was to estimate the effect of sleep duration on prospective type 2 diabetes (T2D) risk across demographic characteristics and follow-up periods, and test body mass index (BMI) as a mediator and moderator.<h4>Methods</h4>Data included adults (M<sub>age</sub> = 39.0 ± 12.7 years) born in the United States or Mexico recruited from 2001 to 2012 in a Mexican American cohort study conducted in Houston, TX (n = 15,779). Participants completed self-reported questionnaires at baseline related to health, health behaviors (sleep duration, physical activity, smoking, drinking), and sociocultural factors and were followed up annually.<h4>Results</h4>Cox proportional hazard models estimated hazard ratios (HR) for the effect of sleep duration on T2D diagnosis at follow-up. Of the participants, 10.3% were diagnosed with T2D. Self-reported ≤5 hours of sleep, compared to 7-8 hours, at baseline predicted greater risk for T2D (HR = 1.32, P = .001), yet was no longer significant after adjusting for sociodemographic characteristics and BMI. Notably, those with BMI <25 kg/m<sup>2</sup> reporting ≤5 hours of sleep were at significant risk for T2D at 3 (HR = 4.13, P = .024) and 5-year follow-up (HR = 3.73, P = .008) compared to 7-8 hours. Obesity status accounted for 31.6% and 27.3% of the variance in the association between ≤5 and 6 hours of sleep and increased T2D risk, respectively.<h4>Conclusions</h4>Results highlighted the mediating and moderating role of BMI, and its effect on T2D risk at earlier follow-up among those without obesity. T2D prevention and control for Mexican American adults should consider the role of chronic sleep loss.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-04T13:18:52.634Z","creation":"2025-04-04T13:18:52.634Z"},"accession":"S-EPMC8370575","cross_references":{"pubmed":["33582048"],"doi":["10.1016/j.sleh.2020.12.003"]}}