{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Warling A"],"funding":["Intramural NIH HHS","NICHD NIH HHS","Medical Research Council","NIMH NIH HHS","National Institute for Health Research (NIHR)"],"pagination":["7015-7028"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8372020"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(33)"],"pubmed_abstract":["Anatomical organization of the primate cortex varies as a function of total brain size, where possession of a larger brain is accompanied by disproportionate expansion of associative cortices alongside a relative contraction of sensorimotor systems. However, equivalent scaling maps are not yet available for regional white matter anatomy. Here, we use three large-scale neuroimaging datasets to examine how regional white matter volume (WMV) scales with interindividual variation in brain volume among typically developing humans (combined <i>N</i> = 2391: 1247 females, 1144 males). We show that WMV scaling is regionally heterogeneous: larger brains have relatively greater WMV in anterior and posterior regions of cortical white matter, as well as the genu and splenium of the corpus callosum, bu"],"journal":["The Journal of neuroscience : the official journal of the Society for Neuroscience"],"pubmed_title":["Regional White Matter Scaling in the Human Brain."],"pmcid":["PMC8372020"],"funding_grant_id":["R01 MH119219","R01 MH120482","NIHR200256","R01 MH112847","NF-SI-0513-10051","ZIA MH002949","P50 HD105351","MC_G0802534"],"pubmed_authors":["Gur RC","Gur RE","Raznahan A","Liu S","Glahn D","Bullmore ET","Nadig A","Roalf D","Moore TM","Seidlitz J","Rodrigue AL","Satterthwaite TD","McDermott CL","Warling A"],"additional_accession":[]},"is_claimable":false,"name":"Regional White Matter Scaling in the Human Brain.","description":"Anatomical organization of the primate cortex varies as a function of total brain size, where possession of a larger brain is accompanied by disproportionate expansion of associative cortices alongside a relative contraction of sensorimotor systems. However, equivalent scaling maps are not yet available for regional white matter anatomy. Here, we use three large-scale neuroimaging datasets to examine how regional white matter volume (WMV) scales with interindividual variation in brain volume among typically developing humans (combined <i>N</i> = 2391: 1247 females, 1144 males). We show that WMV scaling is regionally heterogeneous: larger brains have relatively greater WMV in anterior and posterior regions of cortical white matter, as well as the genu and splenium of the corpus callosum, bu","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2026-04-08T17:49:03.794Z","creation":"2025-04-04T07:56:57.126Z"},"accession":"S-EPMC8372020","cross_references":{"pubmed":["34244364"],"doi":["10.1523/JNEUROSCI.1193-21.2021","10.1523/jneurosci.1193-21.2021"]}}