biostudies-literatureWarling AIntramural NIH HHSNICHD NIH HHSMedical Research CouncilNIMH NIH HHSNational Institute for Health Research (NIHR)7015-7028https://www.ebi.ac.uk/biostudies/studies/S-EPMC8372020biostudies-literatureUnknown41(33)Anatomical organization of the primate cortex varies as a function of total brain size, where possession of a larger brain is accompanied by disproportionate expansion of associative cortices alongside a relative contraction of sensorimotor systems. However, equivalent scaling maps are not yet available for regional white matter anatomy. Here, we use three large-scale neuroimaging datasets to examine how regional white matter volume (WMV) scales with interindividual variation in brain volume among typically developing humans (combined <i>N</i> = 2391: 1247 females, 1144 males). We show that WMV scaling is regionally heterogeneous: larger brains have relatively greater WMV in anterior and posterior regions of cortical white matter, as well as the genu and splenium of the corpus callosum, buThe Journal of neuroscience : the official journal of the Society for NeuroscienceRegional White Matter Scaling in the Human Brain.PMC8372020R01 MH119219R01 MH120482NIHR200256R01 MH112847NF-SI-0513-10051ZIA MH002949P50 HD105351MC_G0802534Gur RCGur RERaznahan ALiu SGlahn DBullmore ETNadig ARoalf DMoore TMSeidlitz JRodrigue ALSatterthwaite TDMcDermott CLWarling AfalseRegional White Matter Scaling in the Human Brain.Anatomical organization of the primate cortex varies as a function of total brain size, where possession of a larger brain is accompanied by disproportionate expansion of associative cortices alongside a relative contraction of sensorimotor systems. However, equivalent scaling maps are not yet available for regional white matter anatomy. Here, we use three large-scale neuroimaging datasets to examine how regional white matter volume (WMV) scales with interindividual variation in brain volume among typically developing humans (combined <i>N</i> = 2391: 1247 females, 1144 males). We show that WMV scaling is regionally heterogeneous: larger brains have relatively greater WMV in anterior and posterior regions of cortical white matter, as well as the genu and splenium of the corpus callosum, bu2021-01-01T00:00:00Z2021 Aug2026-04-08T17:49:03.794Z2025-04-04T07:56:57.126ZS-EPMC83720203424436410.1523/JNEUROSCI.1193-21.202110.1523/jneurosci.1193-21.2021