{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":55,"searchCount":0},"additional":{"submitter":["Wang Y"],"funding":["Public Welfare Science and Technology Plan Project of Ningbo, Major social development projects of Ningbo"],"pagination":["e23893"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8373326"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["35(8)"],"pubmed_abstract":["<h4>Objective</h4>To clarify the role of miR-92a in regulating the malignant progression of cervical cancer and its specific molecular mechanism.<h4>Methods</h4>qRT-PCR was used to detect the differential expression of miR-92a in cervical cancer and adjacent tissues. The effects of overexpression of miR-92a on the proliferation, migration, and invasion of HeLa and SiHa cells were tested. Luciferase assays and rescue experiments were used to investigate the regulatory mechanism of miR-92a on its downstream gene PIK3R1 and their interaction in the progression of cervical cancer.<h4>Results</h4>miR-92a was significantly up-regulated in cervical cancer tissues. Overexpression of miR-92a significantly increased the ability of cervical cancer cells to proliferate, migrate, and invade. PIK3R1 was identified as a downstream gene of miR-92a. In cervical cancer tissues, PIK3R1 was found to be down-regulated and negatively correlated with the level of miR-92a. Overexpression of PIK3R1 reversed the promotional effect of overexpressed miR-92a on the proliferation, migration, and invasion of cervical cancer.<h4>Conclusion</h4>miR-92a is up-regulated in cervical cancer tissues. miR-92a promotes the malignant development of cervical cancer by negatively regulating PIK3R1."],"journal":["Journal of clinical laboratory analysis"],"pubmed_title":["miR-92a promotes cervical cancer cell proliferation, invasion, and migration by directly targeting PIK3R1."],"pmcid":["PMC8373326"],"funding_grant_id":["2013C51015"],"pubmed_authors":["Chen A","Zhao L","Zheng C","Wang Y"],"view_count":["55"],"additional_accession":[]},"is_claimable":false,"name":"miR-92a promotes cervical cancer cell proliferation, invasion, and migration by directly targeting PIK3R1.","description":"<h4>Objective</h4>To clarify the role of miR-92a in regulating the malignant progression of cervical cancer and its specific molecular mechanism.<h4>Methods</h4>qRT-PCR was used to detect the differential expression of miR-92a in cervical cancer and adjacent tissues. The effects of overexpression of miR-92a on the proliferation, migration, and invasion of HeLa and SiHa cells were tested. Luciferase assays and rescue experiments were used to investigate the regulatory mechanism of miR-92a on its downstream gene PIK3R1 and their interaction in the progression of cervical cancer.<h4>Results</h4>miR-92a was significantly up-regulated in cervical cancer tissues. Overexpression of miR-92a significantly increased the ability of cervical cancer cells to proliferate, migrate, and invade. PIK3R1 was identified as a downstream gene of miR-92a. In cervical cancer tissues, PIK3R1 was found to be down-regulated and negatively correlated with the level of miR-92a. Overexpression of PIK3R1 reversed the promotional effect of overexpressed miR-92a on the proliferation, migration, and invasion of cervical cancer.<h4>Conclusion</h4>miR-92a is up-regulated in cervical cancer tissues. miR-92a promotes the malignant development of cervical cancer by negatively regulating PIK3R1.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2024-10-17T19:52:50.661Z","creation":"2022-02-11T09:33:31.481Z"},"accession":"S-EPMC8373326","cross_references":{"pubmed":["34216514"],"doi":["10.1002/jcla.23893"]}}