{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Liang C"],"pubmed_abstract":["As a basic structure of most polypyridinal metal complexes, [Ru(bpy)<sub>3</sub>]<sup>2+</sup>, has the advantages of simple structure, facile synthesis and high yield, which has great potential for scientific research and application. However, sonodynamic therapy (SDT) performance of [Ru(bpy)<sub>3</sub>]<sup>2+</sup> has not been investigated so far. SDT can overcome the tissue-penetration and phototoxicity problems compared to photodynamic therapy. Here, we report that [Ru(bpy)<sub>3</sub>]<sup>2+</sup> is a highly potent sonosensitizer and sonocatalyst for sonotherapy in vitro and in vivo. [Ru(bpy)<sub>3</sub>]<sup>2+</sup> can produce singlet oxygen (<sup>1</sup>O<sub>2</sub>) and sono-oxidize endogenous 1,4-dihydronicotinamide adenine dinucleotide (NADH) under ultrasound (US) stimula"],"journal":["Nature communications"],"pagination":["5001"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8373944"],"repository":["biostudies-literature"],"pubmed_title":["A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy."],"pmcid":["PMC8373944"],"pubmed_authors":["Liang C","Huang C","Xie J","Huang H","Luo S","Zhang Q","Zhang P"],"additional_accession":[]},"is_claimable":false,"name":"A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy.","description":"As a basic structure of most polypyridinal metal complexes, [Ru(bpy)<sub>3</sub>]<sup>2+</sup>, has the advantages of simple structure, facile synthesis and high yield, which has great potential for scientific research and application. However, sonodynamic therapy (SDT) performance of [Ru(bpy)<sub>3</sub>]<sup>2+</sup> has not been investigated so far. SDT can overcome the tissue-penetration and phototoxicity problems compared to photodynamic therapy. Here, we report that [Ru(bpy)<sub>3</sub>]<sup>2+</sup> is a highly potent sonosensitizer and sonocatalyst for sonotherapy in vitro and in vivo. [Ru(bpy)<sub>3</sub>]<sup>2+</sup> can produce singlet oxygen (<sup>1</sup>O<sub>2</sub>) and sono-oxidize endogenous 1,4-dihydronicotinamide adenine dinucleotide (NADH) under ultrasound (US) stimula","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2026-05-09T02:26:38.794Z","creation":"2026-04-08T00:35:25.627Z"},"accession":"S-EPMC8373944","cross_references":{"pubmed":["34408151"],"doi":["10.1038/s41467-021-25303-1"]}}