biostudies-literatureUnknown11(1)Khoobchandani MDhanvantari Nano Ayushadi Private Limited (DNA), Chennai, IndiaUniversity of Missouri, Department of Radiology and Institute of Green NanotechnologyResearch Project (CRP, No. 18316), from the United Nation’s International Atomic Energy Agency (IAEA), Vienna, AustriaMen with castration-resistant prostate cancer (CRPC) face poor prognosis and increased risk of treatment-incurred adverse effects resulting in one of the highest mortalities among patient population globally. Immune cells act as double-edged sword depending on the tumor microenvironment, which leads to increased infiltration of pro-tumor (M2) macrophages. Development of new immunomodulatory therapeutic agents capable of targeting the tumor microenvironment, and hence orchestrating the transformation of pro-tumor M2 macrophages to anti-tumor M1, would substantially improve treatment outcomes of CRPC patients. We report, herein, Mangiferin functionalized gold nanoparticulate agent (MGF-AuNPs) and its immunomodulatory characteristics in treating prostate cancer. We provide evidence of immunomScientific reports16797https://www.ebi.ac.uk/biostudies/studies/S-EPMC8373987biostudies-literatureGreen nanotechnology of MGF-AuNPs for immunomodulatory intervention in prostate cancer therapy.PMC8373987Katti KVThipe VCMohanDoss DKDKatti KKHans CPKhan ALugao ABKhoobchandani MAl-Yasiri AYNicholl MBfalseGreen nanotechnology of MGF-AuNPs for immunomodulatory intervention in prostate cancer therapy.Men with castration-resistant prostate cancer (CRPC) face poor prognosis and increased risk of treatment-incurred adverse effects resulting in one of the highest mortalities among patient population globally. Immune cells act as double-edged sword depending on the tumor microenvironment, which leads to increased infiltration of pro-tumor (M2) macrophages. Development of new immunomodulatory therapeutic agents capable of targeting the tumor microenvironment, and hence orchestrating the transformation of pro-tumor M2 macrophages to anti-tumor M1, would substantially improve treatment outcomes of CRPC patients. We report, herein, Mangiferin functionalized gold nanoparticulate agent (MGF-AuNPs) and its immunomodulatory characteristics in treating prostate cancer. We provide evidence of immunom2021-01-01T00:00:00Z2021 Aug2026-05-08T05:18:16.718Z2022-02-11T08:52:38.539ZS-EPMC83739873440823110.1038/s41598-021-96224-8