{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bush MA"],"funding":["National Institute of Allergy and Infectious Diseases","NIAID NIH HHS","NHLBI NIH HHS","National Heart, Lung, and Blood Institute","National Health and Medical Research Council","Center for Integrated Healthcare, U.S. Department of Veterans Affairs"],"pagination":["e21805"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8375618"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["35(9)"],"pubmed_abstract":["A layer of glycocalyx covers the vascular endothelium serving important protective and homeostatic functions. The objective of this study was to determine if breakdown of the endothelial glycocalyx (eGC) occurs during malaria infection in children. Measures of eGC integrity, endothelial activation, and microvascular reactivity were prospectively evaluated in 146 children: 44 with moderately severe malaria (MSM), 42 with severe malaria (SM), and 60 healthy controls (HC). Biochemical measures of eGC integrity included plasma syndecan-1 and total urinary glycosaminoglycans (GAG). Side-stream dark field imaging was used to quantitatively assess integrity of eGC. Plasma angiopoietin-2 (Ang-2) was measured as a marker of endothelial activation and also as a possible mediator of eGC breakdown. Ou"],"journal":["FASEB journal : official publication of the Federation of American Societies for Experimental Biology"],"pubmed_title":["Degradation of endothelial glycocalyx in Tanzanian children with falciparum malaria."],"pmcid":["PMC8375618"],"funding_grant_id":["AI116869","R01 HL130763","R21 AI041764","1135820","K23 AI116869","2772","R01 AI041764","HL130763","R34 AI100784"],"pubmed_authors":["Yeo TW","Granger DL","Florence SM","Mwaikambo ED","Bush MA","Chen Y","Anstey NM","Weinberg JB","Kalingonji AR","Rubach MP"],"additional_accession":[]},"is_claimable":false,"name":"Degradation of endothelial glycocalyx in Tanzanian children with falciparum malaria.","description":"A layer of glycocalyx covers the vascular endothelium serving important protective and homeostatic functions. The objective of this study was to determine if breakdown of the endothelial glycocalyx (eGC) occurs during malaria infection in children. Measures of eGC integrity, endothelial activation, and microvascular reactivity were prospectively evaluated in 146 children: 44 with moderately severe malaria (MSM), 42 with severe malaria (SM), and 60 healthy controls (HC). Biochemical measures of eGC integrity included plasma syndecan-1 and total urinary glycosaminoglycans (GAG). Side-stream dark field imaging was used to quantitatively assess integrity of eGC. Plasma angiopoietin-2 (Ang-2) was measured as a marker of endothelial activation and also as a possible mediator of eGC breakdown. Ou","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-04T09:37:21.707Z","creation":"2025-04-04T09:37:21.707Z"},"accession":"S-EPMC8375618","cross_references":{"pubmed":["34403544"],"doi":["10.1096/fj.202100277RR","10.1096/fj.202100277rr"]}}