{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mehdizadeh Gohari I"],"funding":["NIAID NIH HHS","HHS | NIH | National Institute of Allergy and Infectious Diseases"],"pagination":["e0027921"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8378477"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["203(18)"],"pubmed_abstract":["Clostridium perfringens toxin production is often regulated by the Agr-like quorum sensing (QS) system signaling the VirS/VirR two-component regulatory system (TCRS), which consists of the VirS membrane sensor histidine kinase and the VirR response regulator. VirS/VirR is known to directly control expression of some genes by binding to a DNA binding motif consisting of two VirR boxes located within 500 bp of the target gene start codon. Alternatively, the VirS/VirR system can indirectly regulate production levels of other proteins by increasing expression of a small regulatory RNA, VR-RNA. Previous studies demonstrated that C. perfringens beta-toxin (CPB) production by C. perfringens type B and C strains is positively regulated by both the Agr-like QS and the VirS/VirR TCRS, but the mechan"],"journal":["Journal of bacteriology"],"pubmed_title":["Identifying the Basis for VirS/VirR Two-Component Regulatory System Control of Clostridium perfringens Beta-Toxin Production."],"pmcid":["PMC8378477"],"funding_grant_id":["R21 AI140010","R21AI140010-02"],"pubmed_authors":["Li J","McClane BA","Mehdizadeh Gohari I"],"additional_accession":[]},"is_claimable":false,"name":"Identifying the Basis for VirS/VirR Two-Component Regulatory System Control of Clostridium perfringens Beta-Toxin Production.","description":"Clostridium perfringens toxin production is often regulated by the Agr-like quorum sensing (QS) system signaling the VirS/VirR two-component regulatory system (TCRS), which consists of the VirS membrane sensor histidine kinase and the VirR response regulator. VirS/VirR is known to directly control expression of some genes by binding to a DNA binding motif consisting of two VirR boxes located within 500 bp of the target gene start codon. Alternatively, the VirS/VirR system can indirectly regulate production levels of other proteins by increasing expression of a small regulatory RNA, VR-RNA. Previous studies demonstrated that C. perfringens beta-toxin (CPB) production by C. perfringens type B and C strains is positively regulated by both the Agr-like QS and the VirS/VirR TCRS, but the mechan","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-18T12:11:39.918Z","creation":"2025-04-06T21:49:38.269Z"},"accession":"S-EPMC8378477","cross_references":{"pubmed":["34228498"],"doi":["10.1128/jb.00279-21","10.1128/JB.00279-21"]}}