{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang R"],"funding":["Natural Science Foundation of Hebei Province","Department of Education of Hebei Province","National Natural Science Foundation of China"],"pagination":["e2101838118"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8379927"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["118(33)"],"pubmed_abstract":["Regulation of the nucleocytoplasmic trafficking of signaling components, especially transcription factors, is a key step of signal transduction in response to extracellular stimuli. In the brassinosteroid (BR) signal transduction pathway, transcription factors from the BRASSINAZOLE RESISTANT1 (BZR1) family are essential in mediating BR-regulated gene expression. The subcellular localization and transcriptional activity of BZR1 are tightly regulated by reversible protein phosphorylation; however, the underlying mechanism is not well understood. Here, we provide evidence that both BZR1 phosphorylation and dephosphorylation occur in the nucleus and that BR-regulated nuclear localization of BZR1 is independent from its interaction with, or dephosphorylation by, protein phosphatase 2A. Using a "],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Nucleocytoplasmic trafficking and turnover mechanisms of BRASSINAZOLE RESISTANT1 in Arabidopsis thaliana."],"pmcid":["PMC8379927"],"funding_grant_id":["C2019205288","31970313，31201063","LJRC015","91417313"],"pubmed_authors":["Liu X","Yang X","Peng Y","Wang R","Liu M","Tang W","Yuan W","Zhao Z","Sun Y"],"additional_accession":[]},"is_claimable":false,"name":"Nucleocytoplasmic trafficking and turnover mechanisms of BRASSINAZOLE RESISTANT1 in Arabidopsis thaliana.","description":"Regulation of the nucleocytoplasmic trafficking of signaling components, especially transcription factors, is a key step of signal transduction in response to extracellular stimuli. In the brassinosteroid (BR) signal transduction pathway, transcription factors from the BRASSINAZOLE RESISTANT1 (BZR1) family are essential in mediating BR-regulated gene expression. The subcellular localization and transcriptional activity of BZR1 are tightly regulated by reversible protein phosphorylation; however, the underlying mechanism is not well understood. Here, we provide evidence that both BZR1 phosphorylation and dephosphorylation occur in the nucleus and that BR-regulated nuclear localization of BZR1 is independent from its interaction with, or dephosphorylation by, protein phosphatase 2A. Using a ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-05T14:05:42.537Z","creation":"2025-04-05T14:05:42.537Z"},"accession":"S-EPMC8379927","cross_references":{"pubmed":["34385302"],"doi":["10.1073/pnas.2101838118"]}}