{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Donati FL"],"funding":["NIMH NIH HHS","National Institute of Mental Health"],"pagination":["110387"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8380703"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["111"],"pubmed_abstract":["Accumulating evidence points to neurophysiological abnormalities of the motor cortex in Schizophrenia (SCZ). However, whether these abnormalities represent a core biological feature of psychosis rather than a superimposed neurodegenerative process is yet to be defined, as it is their putative relationship with clinical symptoms. in this study, we used Transcranial Magnetic Stimulation coupled with electroencephalography (TMS-EEG) to probe the intrinsic oscillatory properties of motor (Brodmann Area 4, BA4) and non-motor (posterior parietal, BA7) cortical areas in twenty-three first-episode psychosis (FEP) patients and thirteen age and gender-matched healthy comparison (HC) subjects. Patients underwent clinical evaluation at baseline and six-months after the TMS-EEG session. We found that F"],"journal":["Progress in neuro-psychopharmacology & biological psychiatry"],"pubmed_title":["Reduced TMS-evoked fast oscillations in the motor cortex predict the severity of positive symptoms in first-episode psychosis."],"pmcid":["PMC8380703"],"funding_grant_id":["R21 MH119543","R01 MH125816"],"pubmed_authors":["Casali AG","Donati FL","D'Agostino A","Reis CC","Kaskie R","Ferrarelli F"],"additional_accession":[]},"is_claimable":false,"name":"Reduced TMS-evoked fast oscillations in the motor cortex predict the severity of positive symptoms in first-episode psychosis.","description":"Accumulating evidence points to neurophysiological abnormalities of the motor cortex in Schizophrenia (SCZ). However, whether these abnormalities represent a core biological feature of psychosis rather than a superimposed neurodegenerative process is yet to be defined, as it is their putative relationship with clinical symptoms. in this study, we used Transcranial Magnetic Stimulation coupled with electroencephalography (TMS-EEG) to probe the intrinsic oscillatory properties of motor (Brodmann Area 4, BA4) and non-motor (posterior parietal, BA7) cortical areas in twenty-three first-episode psychosis (FEP) patients and thirteen age and gender-matched healthy comparison (HC) subjects. Patients underwent clinical evaluation at baseline and six-months after the TMS-EEG session. We found that F","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-04T01:23:51.388Z","creation":"2025-04-04T01:23:51.388Z"},"accession":"S-EPMC8380703","cross_references":{"pubmed":["34129889"],"doi":["10.1016/j.pnpbp.2021.110387"]}}