biostudies-literatureDonati FLNIMH NIH HHSNational Institute of Mental Health110387https://www.ebi.ac.uk/biostudies/studies/S-EPMC8380703biostudies-literatureUnknown111Accumulating evidence points to neurophysiological abnormalities of the motor cortex in Schizophrenia (SCZ). However, whether these abnormalities represent a core biological feature of psychosis rather than a superimposed neurodegenerative process is yet to be defined, as it is their putative relationship with clinical symptoms. in this study, we used Transcranial Magnetic Stimulation coupled with electroencephalography (TMS-EEG) to probe the intrinsic oscillatory properties of motor (Brodmann Area 4, BA4) and non-motor (posterior parietal, BA7) cortical areas in twenty-three first-episode psychosis (FEP) patients and thirteen age and gender-matched healthy comparison (HC) subjects. Patients underwent clinical evaluation at baseline and six-months after the TMS-EEG session. We found that FProgress in neuro-psychopharmacology & biological psychiatryReduced TMS-evoked fast oscillations in the motor cortex predict the severity of positive symptoms in first-episode psychosis.PMC8380703R21 MH119543R01 MH125816Casali AGDonati FLD'Agostino AReis CCKaskie RFerrarelli FfalseReduced TMS-evoked fast oscillations in the motor cortex predict the severity of positive symptoms in first-episode psychosis.Accumulating evidence points to neurophysiological abnormalities of the motor cortex in Schizophrenia (SCZ). However, whether these abnormalities represent a core biological feature of psychosis rather than a superimposed neurodegenerative process is yet to be defined, as it is their putative relationship with clinical symptoms. in this study, we used Transcranial Magnetic Stimulation coupled with electroencephalography (TMS-EEG) to probe the intrinsic oscillatory properties of motor (Brodmann Area 4, BA4) and non-motor (posterior parietal, BA7) cortical areas in twenty-three first-episode psychosis (FEP) patients and thirteen age and gender-matched healthy comparison (HC) subjects. Patients underwent clinical evaluation at baseline and six-months after the TMS-EEG session. We found that F2021-01-01T00:00:00Z2021 Dec2025-04-04T01:23:51.388Z2025-04-04T01:23:51.388ZS-EPMC83807033412988910.1016/j.pnpbp.2021.110387