biostudies-literatureSobrin LNEI NIH HHSNational Institutes of HealthUniversity of Pennsylvania Core25-30https://www.ebi.ac.uk/biostudies/studies/S-EPMC8380755biostudies-literatureUnknown29(1)<h4>Purpose</h4>To determine if angiotensin converting enzyme-inhibitors (ACE-I) alter the incidence of non-infectious uveitis (NIU).<h4>Methods</h4>Patients in a large healthcare claims database who initiated ACE-I (n = 695,557) were compared to patients who initiated angiotensin receptor blockers (ARB, n = 354,295). A second comparison was also made between patients who initiated ACE-I (n = 505,958) and those who initiated beta-blockers (BB, n = 538,109). The primary outcome was incident NIU defined as a first diagnosis code for NIU followed by a second instance of a NIU code within 120 days. For the secondary outcome, a corticosteroid prescription or code for an ocular corticosteroid injection within 120 days of the NIU diagnosis code was used instead of the second NIU diagnosis code. DOphthalmic epidemiologyAngiotensin Converting Enzyme-Inhibitors and Incidence of Non-infectious Uveitis in a Large Healthcare Claims Database.PMC8380755P30 EY001583R21 EY029851VanderBeek BLKempen JHHubbard RASobrin LLi AYu YfalseAngiotensin Converting Enzyme-Inhibitors and Incidence of Non-infectious Uveitis in a Large Healthcare Claims Database.<h4>Purpose</h4>To determine if angiotensin converting enzyme-inhibitors (ACE-I) alter the incidence of non-infectious uveitis (NIU).<h4>Methods</h4>Patients in a large healthcare claims database who initiated ACE-I (n = 695,557) were compared to patients who initiated angiotensin receptor blockers (ARB, n = 354,295). A second comparison was also made between patients who initiated ACE-I (n = 505,958) and those who initiated beta-blockers (BB, n = 538,109). The primary outcome was incident NIU defined as a first diagnosis code for NIU followed by a second instance of a NIU code within 120 days. For the secondary outcome, a corticosteroid prescription or code for an ocular corticosteroid injection within 120 days of the NIU diagnosis code was used instead of the second NIU diagnosis code. D2022-01-01T00:00:00Z2022 Feb2025-04-04T01:24:14.831Z2025-04-04T01:24:14.831ZS-EPMC83807553362216610.1080/09286586.2021.1887284