biostudies-literatureUnknown14Nguyen DThere is a lack of reliable molecular markers for Parkinson's disease (PD) patients and at-risk individuals. The detection of the pre-symptomatic population of PD will empower more effective clinical intervention to delay or prevent disease onset. We have previously found that the mitochondrial protein Miro1 is resistant to mitochondrial depolarization-induced degradation in fibroblasts from a large number of PD patients and several at-risk individuals. Therefore, Miro1 has the potential to molecularly label PD populations. In order to determine whether Miro1 could serve as a molecular marker for the risk of PD, here we examine the Miro1 response to mitochondrial depolarization by biochemical approaches in induced pluripotent stem cells from a cohort of at-risk individuals. Our results shoFrontiers in molecular neuroscience734273https://www.ebi.ac.uk/biostudies/studies/S-EPMC8381147biostudies-literatureMiro1 Impairment in a Parkinson's At-Risk Cohort.PMC8381147Nandakishore PConradson DMNguyen DWang XBharat VfalseMiro1 Impairment in a Parkinson's At-Risk Cohort.There is a lack of reliable molecular markers for Parkinson's disease (PD) patients and at-risk individuals. The detection of the pre-symptomatic population of PD will empower more effective clinical intervention to delay or prevent disease onset. We have previously found that the mitochondrial protein Miro1 is resistant to mitochondrial depolarization-induced degradation in fibroblasts from a large number of PD patients and several at-risk individuals. Therefore, Miro1 has the potential to molecularly label PD populations. In order to determine whether Miro1 could serve as a molecular marker for the risk of PD, here we examine the Miro1 response to mitochondrial depolarization by biochemical approaches in induced pluripotent stem cells from a cohort of at-risk individuals. Our results sho2021-01-01T00:00:00Z20212025-04-04T22:43:32.775Z2022-02-11T09:46:04.742ZS-EPMC83811473443409010.3389/fnmol.2021.734273