biostudies-literatureWang XFundamental Research Funds for the Central UniversitiesResearch Grants Council, University Grants CommitteeNational Natural Science Foundation of Chinae2021GH000455https://www.ebi.ac.uk/biostudies/studies/S-EPMC8381858biostudies-literatureUnknown5(8)The ongoing coronavirus disease 2019 (COVID-19) pandemic has caused more than 150 million cases of infection to date and poses a serious threat to global public health. In this study, global COVID-19 data were used to examine the dynamical variations from the perspectives of immunity and contact of 84 countries across the five climate regions: tropical, arid, temperate, and cold. A new approach named Yi Hua Jie Mu is proposed to obtain the transmission rates based on the COVID-19 data between the countries with the same climate region over the Northern Hemisphere and Southern Hemisphere. Our results suggest that the COVID-19 pandemic will persist over a long period of time or enter into regular circulation in multiple periods of 1-2 years. Moreover, based on the simulated results by the COGeoHealthDynamical Variations of the Global COVID-19 Pandemic Based on a SEICR Disease Model: A New Approach of Yi Hua Jie Mu.PMC8381858E119030115205119GK202003005GK20200703911771373Yin GHe DLi JZhou QHu ZFeng XWang XHu QTeng ZCui QfalseDynamical Variations of the Global COVID-19 Pandemic Based on a SEICR Disease Model: A New Approach of Yi Hua Jie Mu.The ongoing coronavirus disease 2019 (COVID-19) pandemic has caused more than 150 million cases of infection to date and poses a serious threat to global public health. In this study, global COVID-19 data were used to examine the dynamical variations from the perspectives of immunity and contact of 84 countries across the five climate regions: tropical, arid, temperate, and cold. A new approach named Yi Hua Jie Mu is proposed to obtain the transmission rates based on the COVID-19 data between the countries with the same climate region over the Northern Hemisphere and Southern Hemisphere. Our results suggest that the COVID-19 pandemic will persist over a long period of time or enter into regular circulation in multiple periods of 1-2 years. Moreover, based on the simulated results by the CO2021-01-01T00:00:00Z2021 Aug2026-05-08T22:04:17.6Z2022-02-11T10:04:26.378ZS-EPMC83818583446676310.1029/2021GH000455