biostudies-literatureUnknown52(3)de Sousa LOThe fungus Paracoccidioides lutzii is one of the species of the Paracoccidioides genus, responsible for a neglected human mycosis, endemic in Latin America, the paracoccidioidomycosis (PCM). In order to survive in the host, the fungus overcomes a hostile environment under low levels of oxygen (hypoxia) during the infectious process. The hypoxia adaptation mechanisms are variable among human pathogenic fungi and worthy to be investigated in Paracoccidoides spp. Previous proteomic results identified that P. lutzii responds to hypoxia and it has a functional homolog of the SrbA transcription factor, a well-described hypoxic regulator. However, the direct regulation of genes by SrbA and the biological processes it governs while performing protein interactions have not been revealed yet. The goBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]1135-1149https://www.ebi.ac.uk/biostudies/studies/S-EPMC8382145biostudies-literatureThe dual role of SrbA from Paracoccidioides lutzii: a hypoxic regulator.PMC8382145de Sousa LOde Sousa Lima Pde Almeida Soares CMOliveira LNNaves RBSantiago Freitas E Silva KPereira ALAfalseThe dual role of SrbA from Paracoccidioides lutzii: a hypoxic regulator.The fungus Paracoccidioides lutzii is one of the species of the Paracoccidioides genus, responsible for a neglected human mycosis, endemic in Latin America, the paracoccidioidomycosis (PCM). In order to survive in the host, the fungus overcomes a hostile environment under low levels of oxygen (hypoxia) during the infectious process. The hypoxia adaptation mechanisms are variable among human pathogenic fungi and worthy to be investigated in Paracoccidoides spp. Previous proteomic results identified that P. lutzii responds to hypoxia and it has a functional homolog of the SrbA transcription factor, a well-described hypoxic regulator. However, the direct regulation of genes by SrbA and the biological processes it governs while performing protein interactions have not been revealed yet. The go2021-01-01T00:00:00Z2021 Sep2026-07-16T11:59:37.758Z2025-04-19T18:19:39.59ZS-EPMC83821453414821610.1007/s42770-021-00527-x