biostudies-literatureUnknown111Chen Y<h4>Aims</h4>To explore the contagiousness and new SARS-CoV-2 mutations in pediatric COVID-19.<h4>Methods</h4>This cohort study enrolled all pediatric patients admitted to 8 hospitals in Zhejiang Province of China between 21 January and 29 February 2020, their family members and close-contact classmates. Epidemiological, demographic, clinical and laboratory data were collected. Bioinformatics was used to analyze the features of SARS-CoV-2. Individuals were divided into 3 groups by the first-generation case: Groups 1 (unclear), 2 (adult), and 3 (child). The secondary attack rate (SAR) and R₀ were compared among the groups.<h4>Results</h4>The infection rate among 211 individuals was 64% (135/211). The SAR in Groups 2 and 3 was 71% (73/103) and 3% (1/30), respectively; the median RInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases347-353https://www.ebi.ac.uk/biostudies/studies/S-EPMC8384730biostudies-literatureThe low contagiousness and new A958D mutation of SARS-CoV-2 in children: An observational cohort study.PMC8384730Hong LWu NChen JLu XWang JZhang QLi WCang XNi YZheng JShu QLi SChen ZYe SFan LFu JChen YWang WYao HXu WShang SCao QfalseThe low contagiousness and new A958D mutation of SARS-CoV-2 in children: An observational cohort study.<h4>Aims</h4>To explore the contagiousness and new SARS-CoV-2 mutations in pediatric COVID-19.<h4>Methods</h4>This cohort study enrolled all pediatric patients admitted to 8 hospitals in Zhejiang Province of China between 21 January and 29 February 2020, their family members and close-contact classmates. Epidemiological, demographic, clinical and laboratory data were collected. Bioinformatics was used to analyze the features of SARS-CoV-2. Individuals were divided into 3 groups by the first-generation case: Groups 1 (unclear), 2 (adult), and 3 (child). The secondary attack rate (SAR) and R₀ were compared among the groups.<h4>Results</h4>The infection rate among 211 individuals was 64% (135/211). The SAR in Groups 2 and 3 was 71% (73/103) and 3% (1/30), respectively; the median R2021-01-01T00:00:00Z2021 Oct2026-05-08T08:20:30.102Z2022-02-11T12:03:30.43ZS-EPMC83847303445412010.1016/j.ijid.2021.08.036