{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kiser ET"],"funding":["BLRD VA","NIAID NIH HHS","U.S. Department of Veterans Affairs","Division of Intramural Research, National Institute of Allergy and Infectious Diseases"],"pagination":["e0042321"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8386445"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(4)"],"pubmed_abstract":["Visceral leishmaniasis is a potentially fatal disease caused by the protozoon Leishmania donovani or L. infantum (Li). Although previous studies revealed that high lipid intake reduces parasite burdens in Leishmania donovani-infected mice, the specific contributions of dietary lipids to Li-associated pathogenesis are not known. To address this, we evaluated parasite growth, liver pathology, and transcriptomic signatures in Li-infected BALB/c mice fed either a control, high-fat, high-cholesterol, or high-fat-high-cholesterol diet. Using quantitative PCR (qPCR), we observed significantly reduced liver parasite burdens in mice fed the high-fat-high-cholesterol diet compared to mice fed the control diet. In contrast to the liver, parasite expansion occurred earlier in the spleens of mice fed t"],"journal":["mSphere"],"pubmed_title":["The Inflammatory Effects of Dietary Lipids Regulate Growth of Parasites during Visceral Leishmaniasis."],"pmcid":["PMC8386445"],"funding_grant_id":["I01 BX001983","T32 AI007511","BX000536","BX001983","I01 BX000536"],"pubmed_authors":["Wacker MA","Dixit UG","Batra-Sharma H","Kiser ET","Chen Y","Wilson ME"],"additional_accession":[]},"is_claimable":false,"name":"The Inflammatory Effects of Dietary Lipids Regulate Growth of Parasites during Visceral Leishmaniasis.","description":"Visceral leishmaniasis is a potentially fatal disease caused by the protozoon Leishmania donovani or L. infantum (Li). Although previous studies revealed that high lipid intake reduces parasite burdens in Leishmania donovani-infected mice, the specific contributions of dietary lipids to Li-associated pathogenesis are not known. To address this, we evaluated parasite growth, liver pathology, and transcriptomic signatures in Li-infected BALB/c mice fed either a control, high-fat, high-cholesterol, or high-fat-high-cholesterol diet. Using quantitative PCR (qPCR), we observed significantly reduced liver parasite burdens in mice fed the high-fat-high-cholesterol diet compared to mice fed the control diet. In contrast to the liver, parasite expansion occurred earlier in the spleens of mice fed t","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-06T04:09:35.921Z","creation":"2022-02-11T10:51:34.706Z"},"accession":"S-EPMC8386445","cross_references":{"pubmed":["34259561"],"doi":["10.1128/mSphere.00423-21"]}}