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It is unclear how inflammation mediated by interleukin 6 (IL-6) in patients with CKD is linked to cardiovascular disease.<h4>Objective</h4>To investigate associations between IL-6 and cardiovascular outcomes in patients with chronic coronary syndrome in association with kidney function.<h4>Design, setting, and participants</h4>This multicenter cohort study included patients enrolled at 663 centers in 39 countries with chronic coronary syndrome who were included in the Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy (STABIL"],"journal":["JAMA cardiology"],"pagination":["1440-1445"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8387946"],"repository":["biostudies-literature"],"pubmed_title":["Interleukin 6 and Cardiovascular Outcomes in Patients With Chronic Kidney Disease and Chronic Coronary Syndrome."],"pmcid":["PMC8387946"],"pubmed_authors":["Tishler SJ","Seung KB","Goldberg AC","Rubenstein CJ","Van Boven AJ","Sanhueza Cardemil 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Chronic kidney disease (CKD) is a risk factor for cardiovascular disease. It is unclear how inflammation mediated by interleukin 6 (IL-6) in patients with CKD is linked to cardiovascular disease.<h4>Objective</h4>To investigate associations between IL-6 and cardiovascular outcomes in patients with chronic coronary syndrome in association with kidney function.<h4>Design, setting, and participants</h4>This multicenter cohort study included patients enrolled at 663 centers in 39 countries with chronic coronary syndrome who were included in the Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy (STABIL","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-22T21:13:26.918Z","creation":"2025-04-06T03:30:22.674Z"},"accession":"S-EPMC8387946","cross_references":{"pubmed":["34431970"],"doi":["10.1001/jamacardio.2021.3079"]}}