biostudies-literatureUnknown12Bosnjak BBundesministerium für Bildung und ForschungDeutsches Zentrum für InfektionsforschungNiedersächsische Ministerium für Wissenschaft und KulturDeutsche ForschungsgemeinschaftHere, we described the case of a B cell-deficient patient after CD19 CAR-T cell therapy for refractory B cell Non-Hodgkin Lymphoma with protracted coronavirus disease 2019 (COVID-19). For weeks, this patient only inefficiently contained the virus while convalescent plasma transfusion correlated with virus clearance. Interestingly, following convalescent plasma therapy natural killer cells matured and virus-specific T cells expanded, presumably allowing virus clearance and recovery from the disease. Our findings, thus, suggest that convalescent plasma therapy can activate cellular immune responses to clear SARS-CoV-2 infections. If confirmed in larger clinical studies, these data could be of general importance for the treatment of COVID-19 patients.Frontiers in immunology721738https://www.ebi.ac.uk/biostudies/studies/S-EPMC8387963biostudies-literatureCase Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy.PMC8387963Steinbruck LBosnjak BGraalmann TGanser AForster RFalk CSStahl KRitter COdak ISchulz TFCornberg MBlasczyk RKoenecke CWedemeyer HHfalseCase Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy.Here, we described the case of a B cell-deficient patient after CD19 CAR-T cell therapy for refractory B cell Non-Hodgkin Lymphoma with protracted coronavirus disease 2019 (COVID-19). For weeks, this patient only inefficiently contained the virus while convalescent plasma transfusion correlated with virus clearance. Interestingly, following convalescent plasma therapy natural killer cells matured and virus-specific T cells expanded, presumably allowing virus clearance and recovery from the disease. Our findings, thus, suggest that convalescent plasma therapy can activate cellular immune responses to clear SARS-CoV-2 infections. If confirmed in larger clinical studies, these data could be of general importance for the treatment of COVID-19 patients.2021-01-01T00:00:00Z20212026-05-08T09:14:16.701Z2026-04-07T23:49:32.041ZS-EPMC83879633445692910.3389/fimmu.2021.721738