biostudies-literatureDorsey MJNCATS NIH HHSNIAID NIH HHSNHLBI NIH HHSNIH Clinical CenterNINDS NIH HHSNCI NIH HHSNational Institutes of HealthOffice of Naval Research38-50https://www.ebi.ac.uk/biostudies/studies/S-EPMC8388237biostudies-literatureUnknown41(1)<h4>Purpose</h4>The Primary Immune Deficiency Treatment Consortium (PIDTC) enrolled children with severe combined immunodeficiency (SCID) in a prospective natural history study of hematopoietic stem cell transplant (HSCT) outcomes over the last decade. Despite newborn screening (NBS) for SCID, infections occurred prior to HSCT. This study's objectives were to define the types and timing of infection prior to HSCT in patients diagnosed via NBS or by family history (FH) and to understand the breadth of strategies employed at PIDTC centers for infection prevention.<h4>Methods</h4>We analyzed retrospective data on infections and pre-transplant management in patients with SCID diagnosed by NBS and/or FH and treated with HSCT between 2010 and 2014. PIDTC centers were surveyed in 2018 to understaJournal of clinical immunologyInfections in Infants with SCID: Isolation, Infection Screening, and Prophylaxis in PIDTC Centers.PMC8388237R13-AI094943P30 CA008748U24-CA76518U54 AI082973U01-TR001263U54 NS064808U10HL069254U01 HL069294U01HL069294U10 HL069254U54-NS064808N00014-13-1-0039R13 AI094943U24 CA076518U01 TR001263U54-AI082973Griffith LMPai SYBednarski JJHaddad EBuckley RHDorsey MJChaudhury SDeSantes KBProckop SAbu-Arja RGoldman FChaimowitz NSPuck JPatel KPSiegel SGillio ABarnum JLQuinones RKohn DBForbes LRButte MJChong HKeller MDChen KHeimall JWright NAMNotarangelo LDAndolina JLogan BDeFelice MLLieberman JACowan MJThakar MSLeiding JWYu LCPulsipher MAMiller HSmith ARDalal JSchultz KRShah AJTorgerson TRQuigg TCJoshi AYChandra SKapoor NOshrine BShyr DBunin NJCuvelier GDEKobrynski LDavila Saldana BJBhatia MKnutsen APVander Lugt MTAquino VBonilla FASeroogy CDvorak CCfalseInfections in Infants with SCID: Isolation, Infection Screening, and Prophylaxis in PIDTC Centers.<h4>Purpose</h4>The Primary Immune Deficiency Treatment Consortium (PIDTC) enrolled children with severe combined immunodeficiency (SCID) in a prospective natural history study of hematopoietic stem cell transplant (HSCT) outcomes over the last decade. Despite newborn screening (NBS) for SCID, infections occurred prior to HSCT. This study's objectives were to define the types and timing of infection prior to HSCT in patients diagnosed via NBS or by family history (FH) and to understand the breadth of strategies employed at PIDTC centers for infection prevention.<h4>Methods</h4>We analyzed retrospective data on infections and pre-transplant management in patients with SCID diagnosed by NBS and/or FH and treated with HSCT between 2010 and 2014. PIDTC centers were surveyed in 2018 to understa2021-01-01T00:00:00Z2021 Jan2026-05-08T02:22:04.569Z2022-02-11T10:05:13.922ZS-EPMC83882373300610910.1007/s10875-020-00865-9