{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Richbourg NR"],"funding":["NIBIB NIH HHS","National Institute of Biomedical Imaging and Bioengineering","National Science Foundation"],"pagination":["2100138"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8389770"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["222(16)"],"pubmed_abstract":["Hydrogels are used in drug delivery applications, chromatography, and tissue engineering to control the rate of solute transport based on solute size and hydrogel-solute affinity. Ongoing modeling efforts to quantify the relationship between hydrogel properties, solute properties, and solute transport contribute toward an increasingly efficient hydrogel design process and provide fundamental insight into the mechanisms relating hydrogel structure and function. However, here we clarify previous conclusions regarding the use of mesh size in hydrogel transport models. We use 3D geometry and hydrogel network visualizations to show that mesh size and junction functionality both contribute to the mesh radius, which determines whether a solute can diffuse within a hydrogel. Using mesh radius inst"],"journal":["Macromolecular chemistry and physics"],"pubmed_title":["Solute Transport Dependence on 3D Geometry of Hydrogel Networks."],"pmcid":["PMC8389770"],"funding_grant_id":["DGE‐1610403","R01 EB022025"],"pubmed_authors":["Peppas NA","Richbourg NR","Ravikumar A"],"additional_accession":[]},"is_claimable":false,"name":"Solute Transport Dependence on 3D Geometry of Hydrogel Networks.","description":"Hydrogels are used in drug delivery applications, chromatography, and tissue engineering to control the rate of solute transport based on solute size and hydrogel-solute affinity. Ongoing modeling efforts to quantify the relationship between hydrogel properties, solute properties, and solute transport contribute toward an increasingly efficient hydrogel design process and provide fundamental insight into the mechanisms relating hydrogel structure and function. However, here we clarify previous conclusions regarding the use of mesh size in hydrogel transport models. We use 3D geometry and hydrogel network visualizations to show that mesh size and junction functionality both contribute to the mesh radius, which determines whether a solute can diffuse within a hydrogel. Using mesh radius inst","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-05T11:29:15.249Z","creation":"2025-04-05T11:29:15.249Z"},"accession":"S-EPMC8389770","cross_references":{"pubmed":["34456531"],"doi":["10.1002/macp.202100138"]}}