{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Piantino J"],"funding":["NHLBI NIH HHS","RRD VA","NINDS NIH HHS"],"pagination":["2391-2399"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8390772"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["38(17)"],"pubmed_abstract":["Impaired clearance of perivascular waste in the brain may play a critical role in morbidity after mild traumatic brain injury (mTBI). We aimed to determine the effect of mTBI on the burden of magnetic resonance imaging (MRI)-visible perivascular spaces (PVSs) in a cohort of U.S. military veterans and whether sleep modulates this effect. We also investigated the correlation between PVS burden and severity of persistent post-concussive symptoms. Fifty-six Iraq/Afghanistan veterans received 3 Tesla MRI as part of a prospective cohort study on military blast mTBI. White matter PVS burden (i.e., number and volume) was calculated using an established automated segmentation algorithm. Multi-variate regression was used to establish the association between mTBIs sustained in the military and PVS bu"],"journal":["Journal of neurotrauma"],"pubmed_title":["Link between Mild Traumatic Brain Injury, Poor Sleep, and Magnetic Resonance Imaging: Visible Perivascular Spaces in Veterans."],"pmcid":["PMC8390772"],"funding_grant_id":["K23 HL150217","I01 RX003087","I01 RX001612","I01 RX000521","R01 NS089709"],"pubmed_authors":["Peskind E","Kleinhans N","Pagulayan K","Piantino J","Schwartz DL","Iliff J","Luther M","Newgard C","Silbert L","Raskind M"],"additional_accession":[]},"is_claimable":false,"name":"Link between Mild Traumatic Brain Injury, Poor Sleep, and Magnetic Resonance Imaging: Visible Perivascular Spaces in Veterans.","description":"Impaired clearance of perivascular waste in the brain may play a critical role in morbidity after mild traumatic brain injury (mTBI). We aimed to determine the effect of mTBI on the burden of magnetic resonance imaging (MRI)-visible perivascular spaces (PVSs) in a cohort of U.S. military veterans and whether sleep modulates this effect. We also investigated the correlation between PVS burden and severity of persistent post-concussive symptoms. Fifty-six Iraq/Afghanistan veterans received 3 Tesla MRI as part of a prospective cohort study on military blast mTBI. White matter PVS burden (i.e., number and volume) was calculated using an established automated segmentation algorithm. Multi-variate regression was used to establish the association between mTBIs sustained in the military and PVS bu","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-04T09:37:45.294Z","creation":"2025-04-04T09:37:45.294Z"},"accession":"S-EPMC8390772","cross_references":{"pubmed":["33599176"],"doi":["10.1089/neu.2020.7447"]}}