{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rodrigues-Amorim D"],"funding":["Fundação para a Ciência e a Tecnologia","Instituto de Salud Carlos III","Axencia Galega de Innovación"],"pagination":["8499"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8395201"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(16)"],"pubmed_abstract":["The neurobiology of schizophrenia is multifactorial, comprising the dysregulation of several biochemical pathways and molecules. This research proposes a peripheral biomarker for schizophrenia that involves the second extracellular loop of norepinephrine transporter (NEText), the tropomyosin receptor kinase C (TrkC), and the neurotrophin-3 (NT-3) in T cells. The study of NEText, NT-3, and TrkC was performed in T cells and plasma extracted from peripheral blood of 54 patients with schizophrenia and 54 healthy controls. Levels of NT-3, TrkC, and NET were significantly lower in plasma and T cells of patients compared to healthy controls. Co-immunoprecipitation (co-IPs) showed protein interactions with Co-IP NEText-NT-3 and Co-IP NEText-TrkC. Computational modelling of protein-peptide docking "],"journal":["International journal of molecular sciences"],"pubmed_title":["The Role of the Second Extracellular Loop of Norepinephrine Transporter, Neurotrophin-3 and Tropomyosin Receptor Kinase C in T Cells: A Peripheral Biomarker in the Etiology of Schizophrenia."],"pmcid":["PMC8395201"],"funding_grant_id":["P16/00405","SFRH/BD/135623/2018","IN607B 2018/17","PI20/00937"],"pubmed_authors":["Garcia-Caballero A","Spuch C","Lopez-Garcia M","Rodrigues-Amorim D","Alvarez-Ariza M","Olivares JM","Freiria-Martinez L","Rodriguez-Jamardo C","Comis-Tuche M","de Las Heras E","Vallejo-Curto MDC","Fernandez-Palleiro P","Iglesias-Martinez-Almeida M","Rivera-Baltanas T"],"additional_accession":[]},"is_claimable":false,"name":"The Role of the Second Extracellular Loop of Norepinephrine Transporter, Neurotrophin-3 and Tropomyosin Receptor Kinase C in T Cells: A Peripheral Biomarker in the Etiology of Schizophrenia.","description":"The neurobiology of schizophrenia is multifactorial, comprising the dysregulation of several biochemical pathways and molecules. This research proposes a peripheral biomarker for schizophrenia that involves the second extracellular loop of norepinephrine transporter (NEText), the tropomyosin receptor kinase C (TrkC), and the neurotrophin-3 (NT-3) in T cells. The study of NEText, NT-3, and TrkC was performed in T cells and plasma extracted from peripheral blood of 54 patients with schizophrenia and 54 healthy controls. Levels of NT-3, TrkC, and NET were significantly lower in plasma and T cells of patients compared to healthy controls. Co-immunoprecipitation (co-IPs) showed protein interactions with Co-IP NEText-NT-3 and Co-IP NEText-TrkC. Computational modelling of protein-peptide docking ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2026-04-08T07:46:31.426Z","creation":"2022-02-11T09:56:57.119Z"},"accession":"S-EPMC8395201","cross_references":{"pubmed":["34445205"],"doi":["10.3390/ijms22168499"]}}