biostudies-literatureUnknown22(16)Djellabi RThe current <i>SARS-CoV-2</i> pandemic causes serious public health, social, and economic issues all over the globe. Surface transmission has been claimed as a possible <i>SARS-CoV-2</i> infection route, especially in heavy contaminated environmental surfaces, including hospitals and crowded public places. Herein, we studied the deactivation of <i>SARS-CoV-2</i> on photoactive AgNPs@TiO₂ coated on industrial ceramic tiles under dark, UVA, and LED light irradiations. <i>SARS-CoV-2</i> inactivation is effective under any light/dark conditions. The presence of AgNPs has an important key to limit the survival of <i>SARS-CoV-2</i> in the dark; moreover, there is a synergistic action when TiO₂ is decorated with Ag to enhance the virus photocatalytic inactivation even under LED. The radical oxidation was confirmed as the the central mechanism behind <i>SARS-CoV-2</i> damage/inactivation by ESR analysis under LED light. Therefore, photoactive AgNPs@TiO₂ ceramic tiles could be exploited to fight surface infections, especially during viral severe pandemics.International journal of molecular sciences8836https://www.ebi.ac.uk/biostudies/studies/S-EPMC8396237biostudies-literatureOxidative Inactivation of SARS-CoV-2 on Photoactive AgNPs@TiO₂ Ceramic Tiles.PMC8396237Bianchi CLDelbue SBasilico NFalletta EParapini SCerrato GDjellabi RD'Alessandro SLaurenti EfalseOxidative Inactivation of SARS-CoV-2 on Photoactive AgNPs@TiO₂ Ceramic Tiles.The current <i>SARS-CoV-2</i> pandemic causes serious public health, social, and economic issues all over the globe. Surface transmission has been claimed as a possible <i>SARS-CoV-2</i> infection route, especially in heavy contaminated environmental surfaces, including hospitals and crowded public places. Herein, we studied the deactivation of <i>SARS-CoV-2</i> on photoactive AgNPs@TiO₂ coated on industrial ceramic tiles under dark, UVA, and LED light irradiations. <i>SARS-CoV-2</i> inactivation is effective under any light/dark conditions. The presence of AgNPs has an important key to limit the survival of <i>SARS-CoV-2</i> in the dark; moreover, there is a synergistic action when TiO₂ is decorated with Ag to enhance the virus photocatalytic inactivation even under LED. The radical oxidation was confirmed as the the central mechanism behind <i>SARS-CoV-2</i> damage/inactivation by ESR analysis under LED light. Therefore, photoactive AgNPs@TiO₂ ceramic tiles could be exploited to fight surface infections, especially during viral severe pandemics.2021-01-01T00:00:00Z2021 Aug2026-04-08T07:19:23.222Z2025-06-01T03:56:48.667ZS-EPMC83962373444554310.3390/ijms22168836