biostudies-literatureLi Hi Shing SSpastic Paraplegia FoundationEU Joint Programme – Neurodegenerative Disease ResearchIrish Institute of Clinical NeuroscienceHealth Research BoardIris O'Brien Foundation107316https://www.ebi.ac.uk/biostudies/studies/S-EPMC8397913biostudies-literatureUnknown38A standardised, single-centre cross-sectional imaging protocol was utilised to investigate cortical grey matter and cerebral white matter alterations in 36 poliomyelitis survivors in contrast to healthy individuals and patients with amyotrophic lateral sclerosis (ALS) as a 'disease-control' group. [1] T1-weighted imaging and 32-direction diffusion tensor imaging data were obtained on a 3 Tesla Philips Achieva MRI system, using an IR-SPGR sequence and SE-EPI sequence respectively. Raw region-of-interest data and percentage change with respect to reference estimated marginal mean values are presented for grey and white matter metrics in key anatomical regions. Poliomyelitis survivors exhibit no frank grey or white matter degeneration. To the contrary, increased partial volumes can be detecteData in briefImaging data indicate cerebral reorganisation in poliomyelitis survivors: Possible compensation for longstanding lower motor neuron pathology.PMC8397913EIA-2017–019Lope JLi Hi Shing SBede PChipika RHHardiman OfalseImaging data indicate cerebral reorganisation in poliomyelitis survivors: Possible compensation for longstanding lower motor neuron pathology.A standardised, single-centre cross-sectional imaging protocol was utilised to investigate cortical grey matter and cerebral white matter alterations in 36 poliomyelitis survivors in contrast to healthy individuals and patients with amyotrophic lateral sclerosis (ALS) as a 'disease-control' group. [1] T1-weighted imaging and 32-direction diffusion tensor imaging data were obtained on a 3 Tesla Philips Achieva MRI system, using an IR-SPGR sequence and SE-EPI sequence respectively. Raw region-of-interest data and percentage change with respect to reference estimated marginal mean values are presented for grey and white matter metrics in key anatomical regions. Poliomyelitis survivors exhibit no frank grey or white matter degeneration. To the contrary, increased partial volumes can be detecte2021-01-01T00:00:00Z2021 Oct2025-04-26T08:38:32.975Z2022-02-11T10:17:52.285ZS-EPMC83979133448564610.1016/j.dib.2021.107316