{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Neves AR"],"funding":["Fundação para a Ciência e a Tecnologia"],"pagination":["1256"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8401607"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(8)"],"pubmed_abstract":["Cancer gene therapy, mediated by non-viral systems, remains a major research focus. To contribute to this field, in this work we reported on the development of dendrimer drug/gene ternary complexes. This innovative approach explored the great capacity of both polyamidoamine (PAMAM)-paclitaxel (PTX) conjugate and polyethylenimine (PEI) polymers to complex a p53-encoding plasmid DNA (pDNA), highlighting the utility of considering two compacting agents. The pDNA complexation capacity has been investigated as function of the nitrogen to phosphate groups ratio (N/P), which revealed to be a tailoring parameter. The physicochemical properties of the conceived ternary complexes were revealed and were found to be promising for cellular transfection. Furthermore, the formulated co-delivery systems d"],"journal":["Pharmaceutics"],"pubmed_title":["Development of Tailor-Made Dendrimer Ternary Complexes for Drug/Gene Co-Delivery in Cancer."],"pmcid":["PMC8401607"],"funding_grant_id":["2020.08310.BD; SFRH/BD/148406/2019 and SFRH/BD/148393/2019"],"pubmed_authors":["Faria R","Biswas S","Neves AR","Paul M","Albuquerque T","Sousa A","Costa D"],"additional_accession":[]},"is_claimable":false,"name":"Development of Tailor-Made Dendrimer Ternary Complexes for Drug/Gene Co-Delivery in Cancer.","description":"Cancer gene therapy, mediated by non-viral systems, remains a major research focus. To contribute to this field, in this work we reported on the development of dendrimer drug/gene ternary complexes. This innovative approach explored the great capacity of both polyamidoamine (PAMAM)-paclitaxel (PTX) conjugate and polyethylenimine (PEI) polymers to complex a p53-encoding plasmid DNA (pDNA), highlighting the utility of considering two compacting agents. The pDNA complexation capacity has been investigated as function of the nitrogen to phosphate groups ratio (N/P), which revealed to be a tailoring parameter. The physicochemical properties of the conceived ternary complexes were revealed and were found to be promising for cellular transfection. Furthermore, the formulated co-delivery systems d","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-26T17:29:43.299Z","creation":"2022-02-11T09:58:56.624Z"},"accession":"S-EPMC8401607","cross_references":{"pubmed":["34452218"],"doi":["10.3390/pharmaceutics13081256"]}}