{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ozpinar EW"],"funding":["NIAID NIH HHS","NIEHS NIH HHS","NIH HHS"],"pagination":["1008-1022"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8403210"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(15-16)"],"pubmed_abstract":["Mast cells (MCs) are pro-inflammatory tissue-resident immune cells that play a key role in inflammation. MCs circulate in peripheral blood as progenitors and undergo terminal differentiation in the tissue microenvironment where they can remain for many years. This <i>in situ</i> maturation results in tissue- and species-specific MC phenotypes, culminating in significant variability in response to environmental stimuli. There are many challenges associated with studying mature tissue-derived MCs, particularly in humans. In cases where cultured MCs are able to differentiate in two-dimensional <i>in vitro</i> cultures, there remains an inability for full maturation. Extracellular matrix (ECM) scaffolds provide for a more physiologically relevant environment for cells <i>in vitro</i> and have "],"journal":["Tissue engineering. Part A"],"pubmed_title":["Dermal Extracellular Matrix-Derived Hydrogels as an <i>In Vitro</i> Substrate to Study Mast Cell Maturation."],"pmcid":["PMC8403210"],"funding_grant_id":["R01 AI143985","T32 OD011130","P30 ES025128"],"pubmed_authors":["Arthur GK","Freytes DO","Mora-Navarro C","Frey AL","Biehl A","Snider DB","Ozpinar EW","Cruse G"],"additional_accession":[]},"is_claimable":false,"name":"Dermal Extracellular Matrix-Derived Hydrogels as an <i>In Vitro</i> Substrate to Study Mast Cell Maturation.","description":"Mast cells (MCs) are pro-inflammatory tissue-resident immune cells that play a key role in inflammation. MCs circulate in peripheral blood as progenitors and undergo terminal differentiation in the tissue microenvironment where they can remain for many years. This <i>in situ</i> maturation results in tissue- and species-specific MC phenotypes, culminating in significant variability in response to environmental stimuli. There are many challenges associated with studying mature tissue-derived MCs, particularly in humans. In cases where cultured MCs are able to differentiate in two-dimensional <i>in vitro</i> cultures, there remains an inability for full maturation. Extracellular matrix (ECM) scaffolds provide for a more physiologically relevant environment for cells <i>in vitro</i> and have ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-04T13:58:41.684Z","creation":"2024-11-07T08:11:04.917Z"},"accession":"S-EPMC8403210","cross_references":{"pubmed":["33003982"],"doi":["10.1089/ten.tea.2020.0142","10.1089/ten.TEA.2020.0142"]}}