{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ding L"],"funding":["Natural Science Foundation of Beijing Municipality","National Natural Science Foundation of China"],"pagination":["875-884"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8403591"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(4)"],"pubmed_abstract":["Cervical cancer (CC) is a type of pelvic malignant tumor that severely threatens women's health. Current evidence suggests that <i>IER5</i>, as a potential radiosensitizer, promotes irradiation-induced apoptosis in CC tissues in patients undergoing chemoradiotherapy. <i>IER5</i> has been shown to be involved in the G<sub>2</sub>/M-phase transition. In the present study, we used <i>Cdc25B</i> as the breakthrough point to explore the underlying mechanism of <i>IER5</i> in the cell cycle regulation of radiation-damaged HeLa cells. <i>IER5</i> was evidently upregulated after irradiation, but <i>Cdc25B</i> was significantly downregulated. In monoclonal <i>IER5</i>-silenced HeLa cells, irradiation-induced downregulation of <i>Cdc25B</i> was attenuated. The effect of irradiation on <i>Cdc25B</i> "],"journal":["Toxicology research"],"pubmed_title":["<i>Cdc25B</i> is transcriptionally inhibited by <i>IER5</i> through the <i>NF-YB</i> transcription factor in irradiation-treated HeLa cells."],"pmcid":["PMC8403591"],"funding_grant_id":["31640022","31770907","7172146"],"pubmed_authors":["Liu X","Zhou P","Jiang X","Xiong Q","Ding K","Ding L","Zhao X"],"additional_accession":[]},"is_claimable":false,"name":"<i>Cdc25B</i> is transcriptionally inhibited by <i>IER5</i> through the <i>NF-YB</i> transcription factor in irradiation-treated HeLa cells.","description":"Cervical cancer (CC) is a type of pelvic malignant tumor that severely threatens women's health. Current evidence suggests that <i>IER5</i>, as a potential radiosensitizer, promotes irradiation-induced apoptosis in CC tissues in patients undergoing chemoradiotherapy. <i>IER5</i> has been shown to be involved in the G<sub>2</sub>/M-phase transition. In the present study, we used <i>Cdc25B</i> as the breakthrough point to explore the underlying mechanism of <i>IER5</i> in the cell cycle regulation of radiation-damaged HeLa cells. <i>IER5</i> was evidently upregulated after irradiation, but <i>Cdc25B</i> was significantly downregulated. In monoclonal <i>IER5</i>-silenced HeLa cells, irradiation-induced downregulation of <i>Cdc25B</i> was attenuated. The effect of irradiation on <i>Cdc25B</i> ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2026-04-08T08:43:32.246Z","creation":"2022-08-04T07:10:47.385Z"},"accession":"S-EPMC8403591","cross_references":{"pubmed":["34484679"],"doi":["10.1093/toxres/tfab069"]}}