{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["25"],"submitter":["Hosen MR"],"funding":["Deutsche Forschungsgemeinschaft","Deutsche Gesellschaft fur Kardiologie - Herz- und Kreislaufforschung eV","Corona Foundation"],"pubmed_abstract":["Long noncoding RNAs (lncRNAs) have emerged as biomarkers and regulators of cardiovascular disease. However, the expression pattern of circulating extracellular vesicle (EV)-incorporated lncRNAs in patients with coronary artery disease (CAD) is still poorly investigated. A human lncRNA array revealed that certain EV-lncRNAs are significantly dysregulated in CAD patients. Circulating small EVs (sEVs) from patients with (n = 30) or without (n = 30) CAD were used to quantify <i>PUNISHER</i> (also known as <i>AGAP2-</i>antisense RNA 1 [<i>AS1</i>]), <i>GAS5</i>, <i>MALAT1</i>, and <i>H19</i> RNA levels. <i>PUNISHER</i> (p = 0.002) and <i>GAS5</i> (p = 0.02) were significantly increased in patients with CAD, compared to non-CAD patients. Fluorescent labeling and quantitative real-time PCR of sEV"],"journal":["Molecular therapy. Nucleic acids"],"pagination":["388-405"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8403722"],"repository":["biostudies-literature"],"pubmed_title":["CAD increases the long noncoding RNA <i>PUNISHER</i> in small extracellular vesicles and regulates endothelial cell function via vesicular shuttling."],"pmcid":["PMC8403722"],"pubmed_authors":["Liu Y","Zietzer A","Goody P","Uchida S","Werner N","Hosen MR","Jansen F","Nickenig G","Li Q","Latz E","Maus K"],"additional_accession":[]},"is_claimable":false,"name":"CAD increases the long noncoding RNA <i>PUNISHER</i> in small extracellular vesicles and regulates endothelial cell function via vesicular shuttling.","description":"Long noncoding RNAs (lncRNAs) have emerged as biomarkers and regulators of cardiovascular disease. However, the expression pattern of circulating extracellular vesicle (EV)-incorporated lncRNAs in patients with coronary artery disease (CAD) is still poorly investigated. A human lncRNA array revealed that certain EV-lncRNAs are significantly dysregulated in CAD patients. Circulating small EVs (sEVs) from patients with (n = 30) or without (n = 30) CAD were used to quantify <i>PUNISHER</i> (also known as <i>AGAP2-</i>antisense RNA 1 [<i>AS1</i>]), <i>GAS5</i>, <i>MALAT1</i>, and <i>H19</i> RNA levels. <i>PUNISHER</i> (p = 0.002) and <i>GAS5</i> (p = 0.02) were significantly increased in patients with CAD, compared to non-CAD patients. Fluorescent labeling and quantitative real-time PCR of sEV","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-19T23:58:42.641Z","creation":"2022-02-11T11:19:15.815Z"},"accession":"S-EPMC8403722","cross_references":{"pubmed":["34484864"],"doi":["10.1016/j.omtn.2021.05.023"]}}