biostudies-literatureClemente-Moragon AEuropean Research Council1001-1011https://www.ebi.ac.uk/biostudies/studies/S-EPMC8404624biostudies-literatureUnknown78(10)<h4>Background</h4>Severe coronavirus disease-2019 (COVID-19) can progress to an acute respiratory distress syndrome (ARDS), which involves alveolar infiltration by activated neutrophils. The beta-blocker metoprolol has been shown to ameliorate exacerbated inflammation in the myocardial infarction setting.<h4>Objectives</h4>The purpose of this study was to evaluate the effects of metoprolol on alveolar inflammation and on respiratory function in patients with COVID-19-associated ARDS.<h4>Methods</h4>A total of 20 COVID-19 patients with ARDS on invasive mechanical ventilation were randomized to metoprolol (15 mg daily for 3 days) or control (no treatment). All patients underwent bronchoalveolar lavage (BAL) before and after metoprolol/control. The safety of metoprolol administration was evaJournal of the American College of CardiologyMetoprolol in Critically Ill Patients With COVID-19.PMC8404624819775Galan-Arriola CIbanez BIoan AMLopez-Alvarez MOliver EFernandez IRodriguez-Gonzalez LSerrano Del Castillo CFuster VClemente-Moragon ASantos AMartinez-Milla JGomez-Talavera SPerez-Calvo CFlandes JfalseMetoprolol in Critically Ill Patients With COVID-19.<h4>Background</h4>Severe coronavirus disease-2019 (COVID-19) can progress to an acute respiratory distress syndrome (ARDS), which involves alveolar infiltration by activated neutrophils. The beta-blocker metoprolol has been shown to ameliorate exacerbated inflammation in the myocardial infarction setting.<h4>Objectives</h4>The purpose of this study was to evaluate the effects of metoprolol on alveolar inflammation and on respiratory function in patients with COVID-19-associated ARDS.<h4>Methods</h4>A total of 20 COVID-19 patients with ARDS on invasive mechanical ventilation were randomized to metoprolol (15 mg daily for 3 days) or control (no treatment). All patients underwent bronchoalveolar lavage (BAL) before and after metoprolol/control. The safety of metoprolol administration was eva2021-01-01T00:00:00Z2021 Sep2026-05-10T05:45:46.578Z2022-02-11T10:14:51.939ZS-EPMC84046243447473110.1016/j.jacc.2021.07.003