{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["127(3)"],"submitter":["Sasaki E"],"pubmed_abstract":["Genome-wide association studies (GWAS) have become a standard approach for exploring the genetic basis of phenotypic variation. However, correlation is not causation, and only a tiny fraction of all associations have been experimentally confirmed. One practical problem is that a peak of association does not always pinpoint a causal gene, but may instead be tagging multiple causal variants. In this study, we reanalyze a previously reported peak associated with flowering time traits in Swedish Arabidopsis thaliana population. The peak appeared to pinpoint the AOP2/AOP3 cluster of glucosinolate biosynthesis genes, which is known to be responsible for natural variation in herbivore resistance. Here we propose an alternative hypothesis, by demonstrating that the AOP2/AOP3 flowering association "],"journal":["Heredity"],"pagination":["245-252"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8405673"],"repository":["biostudies-literature"],"pubmed_title":["Revisiting a GWAS peak in Arabidopsis thaliana reveals possible confounding by genetic heterogeneity."],"pmcid":["PMC8405673"],"pubmed_authors":["Filiault DL","Sasaki E","Nordborg M","Kocher T"],"additional_accession":[]},"is_claimable":false,"name":"Revisiting a GWAS peak in Arabidopsis thaliana reveals possible confounding by genetic heterogeneity.","description":"Genome-wide association studies (GWAS) have become a standard approach for exploring the genetic basis of phenotypic variation. However, correlation is not causation, and only a tiny fraction of all associations have been experimentally confirmed. One practical problem is that a peak of association does not always pinpoint a causal gene, but may instead be tagging multiple causal variants. In this study, we reanalyze a previously reported peak associated with flowering time traits in Swedish Arabidopsis thaliana population. The peak appeared to pinpoint the AOP2/AOP3 cluster of glucosinolate biosynthesis genes, which is known to be responsible for natural variation in herbivore resistance. Here we propose an alternative hypothesis, by demonstrating that the AOP2/AOP3 flowering association ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-04T09:37:48.523Z","creation":"2025-04-04T09:37:48.523Z"},"accession":"S-EPMC8405673","cross_references":{"pubmed":["34226672"],"doi":["10.1038/s41437-021-00456-3"]}}