{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["La Montagna M"],"funding":["Cancer Research UK"],"pagination":["2673-2689"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8408205"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(9)"],"pubmed_abstract":["AMP-activated protein kinase (AMPK) is a critical sensor of energy status that coordinates cell growth with energy balance. In non-small cell lung cancer (NSCLC) the role of AMPKα is controversial and its contribution to lung carcinogenesis is not well-defined. Furthermore, it remains largely unknown whether long non-coding RNAs (lncRNAs) are involved in the regulation of AMPK-mediated pathways. Here, we found that loss of AMPKα in combination with activation of mutant KRAS<sup>G12D</sup> increased lung tumour burden and reduced survival in Kras<sup>LSLG12D/+</sup>/AMPKα<sup>fl/fl</sup> mice. In agreement, functional in vitro studies revealed that AMPKα silencing increased growth and migration of NSCLC cells. In addition, we identified an AMPKα-modulated lncRNA, KIMAT1 (ENSG00000228709), w"],"journal":["Cell death and differentiation"],"pubmed_title":["AMPKα loss promotes KRAS-mediated lung tumorigenesis."],"pmcid":["PMC8408205"],"funding_grant_id":["C5759/A20971"],"pubmed_authors":["La Montagna M","Shi L","Magee P","Sahoo S","Fassan M","Garofalo M"],"additional_accession":[]},"is_claimable":false,"name":"AMPKα loss promotes KRAS-mediated lung tumorigenesis.","description":"AMP-activated protein kinase (AMPK) is a critical sensor of energy status that coordinates cell growth with energy balance. In non-small cell lung cancer (NSCLC) the role of AMPKα is controversial and its contribution to lung carcinogenesis is not well-defined. Furthermore, it remains largely unknown whether long non-coding RNAs (lncRNAs) are involved in the regulation of AMPK-mediated pathways. Here, we found that loss of AMPKα in combination with activation of mutant KRAS<sup>G12D</sup> increased lung tumour burden and reduced survival in Kras<sup>LSLG12D/+</sup>/AMPKα<sup>fl/fl</sup> mice. In agreement, functional in vitro studies revealed that AMPKα silencing increased growth and migration of NSCLC cells. In addition, we identified an AMPKα-modulated lncRNA, KIMAT1 (ENSG00000228709), w","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-18T22:27:08.658Z","creation":"2025-04-07T10:13:21.652Z"},"accession":"S-EPMC8408205","cross_references":{"pubmed":["34040167"],"doi":["10.1038/s41418-021-00777-0"]}}