{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim JH"],"funding":["Ministry of Science, ICT and Future Planning (MSIP)","Ministry of Science, ICT and Future Planning"],"pagination":["2571-2588"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8408247"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(9)"],"pubmed_abstract":["Hevin, also known as SPARC-like protein 1 (SPARCL1 or SC1), is a synaptogenic protein secreted by astrocytes and modulates the formation of glutamatergic synapses in the developing brain by interacting with synaptic adhesion proteins, such as neurexin and neuroligin. Here, we identified the neuron-specific vesicular protein calcyon as a novel interaction partner of hevin and demonstrated that this interaction played a pivotal role in synaptic reorganization after an injury in the mature brain. Astrocytic hevin was upregulated post-injury in a photothrombotic stroke model. Hevin was fragmented by MMP3 induced during the acute stage of brain injury, and this process was associated with severe gliosis. At the late stage, the functional hevin level was restored as MMP3 expression decreased. Th"],"journal":["Cell death and differentiation"],"pubmed_title":["Hevin-calcyon interaction promotes synaptic reorganization after brain injury."],"pmcid":["PMC8408247"],"funding_grant_id":["2017M3C7A1043842","2016M3C7A1904148"],"pubmed_authors":["Lee YS","Hwang EM","Kim A","Shim HS","Lee J","Jung HG","Hyeon SJ","Ryu H","Jung JH","Park JY","Kim JH","Han J","Suk K"],"additional_accession":[]},"is_claimable":false,"name":"Hevin-calcyon interaction promotes synaptic reorganization after brain injury.","description":"Hevin, also known as SPARC-like protein 1 (SPARCL1 or SC1), is a synaptogenic protein secreted by astrocytes and modulates the formation of glutamatergic synapses in the developing brain by interacting with synaptic adhesion proteins, such as neurexin and neuroligin. Here, we identified the neuron-specific vesicular protein calcyon as a novel interaction partner of hevin and demonstrated that this interaction played a pivotal role in synaptic reorganization after an injury in the mature brain. Astrocytic hevin was upregulated post-injury in a photothrombotic stroke model. Hevin was fragmented by MMP3 induced during the acute stage of brain injury, and this process was associated with severe gliosis. At the late stage, the functional hevin level was restored as MMP3 expression decreased. Th","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2026-05-28T04:06:04.684Z","creation":"2025-02-19T03:29:43.492Z"},"accession":"S-EPMC8408247","cross_references":{"pubmed":["33753902"],"doi":["10.1038/s41418-021-00772-5"]}}