{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McNamee JJ"],"funding":["National Institute for Health Research (NIHR)","Health Research Board","Public Health Agency"],"pagination":["1013-1023"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8408762"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["326(11)"],"pubmed_abstract":["Importance
In patients who require mechanical ventilation for acute hypoxemic respiratory failure, further reduction in tidal volumes, compared with conventional low tidal volume ventilation, may improve outcomes.Objective
To determine whether lower tidal volume mechanical ventilation using extracorporeal carbon dioxide removal improves outcomes in patients with acute hypoxemic respiratory failure.Design, setting, and participants
This multicenter, randomized, allocation-concealed, open-label, pragmatic clinical trial enrolled 412 adult patients receiving mechanical ventilation for acute hypoxemic respiratory failure, of a planned sample size of 1120, between May 2016 and December 2019 from 51 intensive care units in the UK. Follow-up ended on March 11, 2020.Int"],"journal":["JAMA"],"pubmed_title":["Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure: The REST Randomized Clinical Trial."],"pmcid":["PMC8408762"],"funding_grant_id":["EAT/5105/14","13/143/02","CTN-2014-012"],"pubmed_authors":["Cabrelli L","Gibson S","Woods L","Drummond A","Young D","Bentley A","Brealey DA","Hu Y","Gunter U","Williams K","Williams J","Charlton M","Angus I","Rae J","Sutton P","James S","Perkins G","Patel S","Wright C","Banach D","Winnard S","Walker J","Salaunkey K","Millar JE","Curtin J","Auzinger G","Grainger L","Christie L","Crews M","Lankester L","Gibson C","Creighton L","McLaughlin M","Felton T","Cocks E","Filipe H","Bodenham A","Hartley L","Andrew G","Summers C","Waugh V","Agus A","Munt S","Howard K","Fitchett J","Zhao X","Kelly A","Patch S","McCulloch C","Morgan MP","Kaur Bhuie P","Jenkins S","Cornell S","Donnelly A","Corbett C","Bean S","Goundry S","Spruce E","Scott SW","Roy A","Bannon L","Vuylsteke A","Turner-Bone I","Pogson D","Cathcart S","Scott TE","Gillies MA","Boyle AJ","Camporota L","Zolfaghari P","Price GC","Ganguly S","McNeil M","Molina E","Dooley N","Raper M","Husain T","Devaramani M","Snelson C","Carter J","Rostron A","Wells C","Muldoon S","McDowell C","Hutter J","Anand Iyer G","Catelan-Zborowski A","Linhartova L","Hill H","Ball J","Farrah H","Farnell S","Ellis K","Tunnicliffe W","Bergin C","McGhee C","Dunn L","Mills J","Campos S","Puxty A","Harkett S","MacGill S","Bercades G","Cahill H","Chukkambotla S","Cabreros L","Lim R","Griffiths M","Nutt C","Nordin N","Adedoyin T","Wilcox D","Gellamucho M","Smyth D","Jackson C","McNamee L","Mpelembue M","Sathianathan V","Walsh T","Cherian S","Dunn MJ","Dempsey G","Gilfeather L","Crooks N","Martin D","Despy L","Bigham C","Dennis A","Mee L","Pooni J","Jacques N","Howcroft C","Dean M","Wilby E","Cooper L","Markham A","Cooper I","Carrera R","Gillon S","Eastgate C","Clark A","Thrush J","Coleman N","Hallett K","Talbot N","Arbane G","Martin T","Ryu J","Doble P","Hodkinson G","Welters I","Cottam V","Ledot S","Davies R","Johnston B","Page V","Innes R","Conway Morris A","Ryan C","Davies M","Tully RP","Gresty J","Barrett NA","Daly Z","Johnston P","Clark R","McCann J","Clark S","Perkins GD","Adeniji K","Dormand N","Champanerkar S","Paton L","Mason N","Shaw D","Henderson S","Docking R","Hass I","Scaife L","Cole J","O'Kane S","Pope M","Cole S","Connaughton E","Mason T","REST Investigators","Ilano D","Melody T","Kennedy-Hay S","Black E","Austin K","Day C","Jones-Criddle C","Sampson J","Austin P","Szakmany T","Polgarova P","Brett S","Harrison-Briggs D","Clement I","Veenith T","Hemmings N","MacCallum NS","McAuley DF","Camsooksai J","Davidson A","Carungcong J","Barclay L","Dermody S","Mackay A","Correia C","Bociek A","Bannard-Smith J","McGinley-Keag L","Gopal S","Andreou P","Singh S","McNamee JJ","Parekh D","Burt K","Hulme J","Brooks J","Birkinshaw I","Brodie D","Paramasivam E","Booth MG","Finney S","Wilding L","Tully R","O'Neill A","Pinto M","Gammon B","Barcraft-Barnes H","Reschreiter H","Whitehouse A","Long F","Ward K","Aherne C","Finney C","Leaver S","Priya Maria J","Templeton M","Walden A","Grau Novellas N","Bowyer C","Rose S","Spivey M","Purdy L","Young NH","Harrison DA","Sim M","Smith H","Whitton C","Smallwood A","Smith J","Maclean S","Kannan S","Whitehouse T","Bhardwaj S","Beale R","Campbell A","Gross J","Mellis C","Couper K","Fellows E","Gordon A","Shanbhag S"],"additional_accession":[]},"is_claimable":false,"name":"Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure: The REST Randomized Clinical Trial.","description":"Importance
In patients who require mechanical ventilation for acute hypoxemic respiratory failure, further reduction in tidal volumes, compared with conventional low tidal volume ventilation, may improve outcomes.Objective
To determine whether lower tidal volume mechanical ventilation using extracorporeal carbon dioxide removal improves outcomes in patients with acute hypoxemic respiratory failure.Design, setting, and participants
This multicenter, randomized, allocation-concealed, open-label, pragmatic clinical trial enrolled 412 adult patients receiving mechanical ventilation for acute hypoxemic respiratory failure, of a planned sample size of 1120, between May 2016 and December 2019 from 51 intensive care units in the UK. Follow-up ended on March 11, 2020.Int","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2026-05-08T19:57:04.456Z","creation":"2025-02-19T03:26:59.489Z"},"accession":"S-EPMC8408762","cross_references":{"pubmed":["34463700"],"doi":["10.1001/jama.2021.13374"]}}