{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ando K"],"funding":["Medical Research Council","NHLBI NIH HHS"],"pagination":["11-22"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8410673"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["479"],"pubmed_abstract":["Platelet derived growth factor beta and its receptor, Pdgfrb, play essential roles in the development of vascular mural cells, including pericytes and vascular smooth muscle cells. To determine if this role was conserved in zebrafish, we analyzed pdgfb and pdgfrb mutant lines. Similar to mouse, pdgfb and pdgfrb mutant zebrafish lack brain pericytes and exhibit anatomically selective loss of vascular smooth muscle coverage. Despite these defects, pdgfrb mutant zebrafish did not otherwise exhibit circulatory defects at larval stages. However, beginning at juvenile stages, we observed severe cranial hemorrhage and vessel dilation associated with loss of pericytes and vascular smooth muscle cells in pdgfrb mutants. Similar to mouse, pdgfrb mutant zebrafish also displayed structural defects in "],"journal":["Developmental biology"],"pubmed_title":["Conserved and context-dependent roles for pdgfrb signaling during zebrafish vascular mural cell development."],"pmcid":["PMC8410673"],"funding_grant_id":["MR/J001457/1","R35 HL140017"],"pubmed_authors":["Gerri C","Fukuhara S","Ebarasi L","Mattonet K","Ando K","Chiba A","Grosse A","Shih YH","Stainier DYR","Lawson ND","Portman D","Mochizuki N","Betsholtz C"],"additional_accession":[]},"is_claimable":false,"name":"Conserved and context-dependent roles for pdgfrb signaling during zebrafish vascular mural cell development.","description":"Platelet derived growth factor beta and its receptor, Pdgfrb, play essential roles in the development of vascular mural cells, including pericytes and vascular smooth muscle cells. To determine if this role was conserved in zebrafish, we analyzed pdgfb and pdgfrb mutant lines. Similar to mouse, pdgfb and pdgfrb mutant zebrafish lack brain pericytes and exhibit anatomically selective loss of vascular smooth muscle coverage. Despite these defects, pdgfrb mutant zebrafish did not otherwise exhibit circulatory defects at larval stages. However, beginning at juvenile stages, we observed severe cranial hemorrhage and vessel dilation associated with loss of pericytes and vascular smooth muscle cells in pdgfrb mutants. Similar to mouse, pdgfrb mutant zebrafish also displayed structural defects in ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2025-04-05T13:44:21.654Z","creation":"2025-04-05T13:44:21.654Z"},"accession":"S-EPMC8410673","cross_references":{"pubmed":["34310924"],"doi":["10.1016/j.ydbio.2021.06.010"]}}