{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(8)"],"submitter":["Yang Q"],"pubmed_abstract":["<h4>Background</h4>The impact of septal myectomy on diastolic function in patients with obstructive hypertrophic cardiomyopathy is not well studied.<h4>Methods</h4>A transcatheter hemodynamic study was performed before and 3 to 6 months after septal myectomy in 12 patients with obstructive hypertrophic cardiomyopathy (HCM).<h4>Results</h4>Postoperative hemodynamic studies were done 4.4±1.2 months after myectomy. The left ventricular outflow tract peak-to-peak gradient decreased from 83.2±43.3 mmHg preoperatively to 11.6±4.3 mmHg after myectomy (P<0.00). The left ventricular diastolic time constant (Tau) was 64.2±26.1 ms before surgery and 42.2±15.7 ms postoperatively (P=0.029). The average left atrial pressure (LAP) decreased from 20.2±7.0 to 12.1±4.5 mmHg after myectomy (P=0.008). Pulmonar"],"journal":["Journal of thoracic disease"],"pagination":["4925-4934"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8411175"],"repository":["biostudies-literature"],"pubmed_title":["Impact of septal myectomy on diastolic function in patients with obstructive hypertrophic cardiomyopathy."],"pmcid":["PMC8411175"],"pubmed_authors":["Lv J","Liu Y","Zhang Y","Wang S","Hu H","Cui H","Yang Q","Schaff HV","Zhu C"],"additional_accession":[]},"is_claimable":false,"name":"Impact of septal myectomy on diastolic function in patients with obstructive hypertrophic cardiomyopathy.","description":"<h4>Background</h4>The impact of septal myectomy on diastolic function in patients with obstructive hypertrophic cardiomyopathy is not well studied.<h4>Methods</h4>A transcatheter hemodynamic study was performed before and 3 to 6 months after septal myectomy in 12 patients with obstructive hypertrophic cardiomyopathy (HCM).<h4>Results</h4>Postoperative hemodynamic studies were done 4.4±1.2 months after myectomy. The left ventricular outflow tract peak-to-peak gradient decreased from 83.2±43.3 mmHg preoperatively to 11.6±4.3 mmHg after myectomy (P<0.00). The left ventricular diastolic time constant (Tau) was 64.2±26.1 ms before surgery and 42.2±15.7 ms postoperatively (P=0.029). The average left atrial pressure (LAP) decreased from 20.2±7.0 to 12.1±4.5 mmHg after myectomy (P=0.008). Pulmonar","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-04T13:57:31.646Z","creation":"2025-04-04T13:57:31.646Z"},"accession":"S-EPMC8411175","cross_references":{"pubmed":["34527331"],"doi":["10.21037/jtd-21-902"]}}