biostudies-literatureUnknown13(8)Yang Q<h4>Background</h4>The impact of septal myectomy on diastolic function in patients with obstructive hypertrophic cardiomyopathy is not well studied.<h4>Methods</h4>A transcatheter hemodynamic study was performed before and 3 to 6 months after septal myectomy in 12 patients with obstructive hypertrophic cardiomyopathy (HCM).<h4>Results</h4>Postoperative hemodynamic studies were done 4.4±1.2 months after myectomy. The left ventricular outflow tract peak-to-peak gradient decreased from 83.2±43.3 mmHg preoperatively to 11.6±4.3 mmHg after myectomy (P<0.00). The left ventricular diastolic time constant (Tau) was 64.2±26.1 ms before surgery and 42.2±15.7 ms postoperatively (P=0.029). The average left atrial pressure (LAP) decreased from 20.2±7.0 to 12.1±4.5 mmHg after myectomy (P=0.008). PulmonarJournal of thoracic disease4925-4934https://www.ebi.ac.uk/biostudies/studies/S-EPMC8411175biostudies-literatureImpact of septal myectomy on diastolic function in patients with obstructive hypertrophic cardiomyopathy.PMC8411175Lv JLiu YZhang YWang SHu HCui HYang QSchaff HVZhu CfalseImpact of septal myectomy on diastolic function in patients with obstructive hypertrophic cardiomyopathy.<h4>Background</h4>The impact of septal myectomy on diastolic function in patients with obstructive hypertrophic cardiomyopathy is not well studied.<h4>Methods</h4>A transcatheter hemodynamic study was performed before and 3 to 6 months after septal myectomy in 12 patients with obstructive hypertrophic cardiomyopathy (HCM).<h4>Results</h4>Postoperative hemodynamic studies were done 4.4±1.2 months after myectomy. The left ventricular outflow tract peak-to-peak gradient decreased from 83.2±43.3 mmHg preoperatively to 11.6±4.3 mmHg after myectomy (P<0.00). The left ventricular diastolic time constant (Tau) was 64.2±26.1 ms before surgery and 42.2±15.7 ms postoperatively (P=0.029). The average left atrial pressure (LAP) decreased from 20.2±7.0 to 12.1±4.5 mmHg after myectomy (P=0.008). Pulmonar2021-01-01T00:00:00Z2021 Aug2025-04-04T13:57:31.646Z2025-04-04T13:57:31.646ZS-EPMC84111753452733110.21037/jtd-21-902