biostudies-literatureMa CHNIBIB NIH HHSNCI NIH HHS2130003https://www.ebi.ac.uk/biostudies/studies/S-EPMC8412167biostudies-literatureUnknown11(2)Photodynamic therapy (PDT) is a two-step procedure that involves the administration of special drugs, commonly called photosensitizers, followed by the application of certain wavelengths of light. The light activates these photosensitizers to produce reactive molecular species that induce cell death in tissues. There are numerous factors to consider when selecting the appropriate photosensitizer administration route, such as which part of the body is being targeted, the pharmacokinetics of photosensitizers, and the formulation of photosensitizers. While intravenous, topical, and oral administration of photosensitizers are widely used in preclinical and clinical applications of PDT, other administration routes, such as intraperitoneal, intra-arterial, and intratumoral injections, are gaininNano LIFEIntratumoral Photosensitizer Delivery and Photodynamic Therapy.PMC8412167R01 CA260340R21 EB028508Yang JMa CHMueller JLHuang HCfalseIntratumoral Photosensitizer Delivery and Photodynamic Therapy.Photodynamic therapy (PDT) is a two-step procedure that involves the administration of special drugs, commonly called photosensitizers, followed by the application of certain wavelengths of light. The light activates these photosensitizers to produce reactive molecular species that induce cell death in tissues. There are numerous factors to consider when selecting the appropriate photosensitizer administration route, such as which part of the body is being targeted, the pharmacokinetics of photosensitizers, and the formulation of photosensitizers. While intravenous, topical, and oral administration of photosensitizers are widely used in preclinical and clinical applications of PDT, other administration routes, such as intraperitoneal, intra-arterial, and intratumoral injections, are gainin2021-01-01T00:00:00Z2021 Jun2025-04-04T22:33:36.833Z2025-02-19T03:24:07.465ZS-EPMC84121673448443510.1142/s179398442130003x