biostudies-literatureSmit DJANICHD NIH HHSNational Institute on Alcohol Abuse and AlcoholismNIDA NIH HHSEpilepsy SocietyNIMH NIH HHSNIAAA NIH HHSBrain and Behavior Research FoundationNational Institutes of HealthAustralian Research CouncilStiftelsen Kristian Gerhard JebsenFreistaat SachsenNorges ForskningsrådEuropean Research CouncilKoninklijke Nederlandse Akademie van WetenschappenNIDDK NIH HHSMinisterio de Ciencia e InnovaciónDutch Research Council (NWO)National Health and Medical Research CouncilNational Institute of Mental HealthNational Institute on Drug AbuseNIH HHSNational Science FoundationEuropean Regional Development Funde02188https://www.ebi.ac.uk/biostudies/studies/S-EPMC8413828biostudies-literatureUnknown11(8)<h4>Background and purpose</h4>The ENIGMA-EEG working group was established to enable large-scale international collaborations among cohorts that investigate the genetics of brain function measured with electroencephalography (EEG). In this perspective, we will discuss why analyzing the genetics of functional brain activity may be crucial for understanding how neurological and psychiatric liability genes affect the brain.<h4>Methods</h4>We summarize how we have performed our currently largest genome-wide association study of oscillatory brain activity in EEG recordings by meta-analyzing the results across five participating cohorts, resulting in the first genome-wide significant hits for oscillatory brain function located in/near genes that were previously associated with psychiatric disorBrain and behaviorLarge-scale collaboration in ENIGMA-EEG: A perspective on the meta-analytic approach to link neurological and psychiatric liability genes to electrophysiological brain activity.PMC8413828R01MH58799‐03K18DC017383R21AA026919024.001.0031926794R01 DK09212701254MH089995MH0899510141321668APP1172917DP0212016U10 AA008401AA008401230374771057R01D0042157-01A1MH081802602768R01 MH058799DA018673DK092127‐04R01D0042157‐01A1PAH/6635A79600334K01DA037914APP1158127A79801419EB020403MH068457‐06DGE‐1926736R21 AA026919AA009367PGC2018‐099013‐A‐I00P50 HD103537DA036216DA005147T32 DA037183284167DP2HD098859U24 MH068457A79906588Jawinski PLuykx JJPorjesz Bde Geus EJCAndreassen OABurwell SJMedland SESander CHensch THegerl UElvsashagen THarper JWright MJIacono WGMalone SMSmit DJABoomsma DIMagne CLSisodiya SMMeyers JLMoberget Tvan Dellen EChorlian DBVia MGordon RLJonsson EGThompson PMvan Beijsterveldt CEMfalseLarge-scale collaboration in ENIGMA-EEG: A perspective on the meta-analytic approach to link neurological and psychiatric liability genes to electrophysiological brain activity.<h4>Background and purpose</h4>The ENIGMA-EEG working group was established to enable large-scale international collaborations among cohorts that investigate the genetics of brain function measured with electroencephalography (EEG). In this perspective, we will discuss why analyzing the genetics of functional brain activity may be crucial for understanding how neurological and psychiatric liability genes affect the brain.<h4>Methods</h4>We summarize how we have performed our currently largest genome-wide association study of oscillatory brain activity in EEG recordings by meta-analyzing the results across five participating cohorts, resulting in the first genome-wide significant hits for oscillatory brain function located in/near genes that were previously associated with psychiatric disor2021-01-01T00:00:00Z2021 Aug2026-05-08T10:09:48.902Z2022-02-11T10:21:26.109ZS-EPMC84138283429159610.1002/brb3.2188