{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kramer B"],"funding":["National Institute for Health Research (NIHR)","Wellcome Trust","Academy of Medical Sciences"],"pagination":["2650-2669.e14"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8416549"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["54(11)"],"pubmed_abstract":["Longitudinal analyses of the innate immune system, including the earliest time points, are essential to understand the immunopathogenesis and clinical course of coronavirus disease (COVID-19). Here, we performed a detailed characterization of natural killer (NK) cells in 205 patients (403 samples; days 2 to 41 after symptom onset) from four independent cohorts using single-cell transcriptomics and proteomics together with functional studies. We found elevated interferon (IFN)-α plasma levels in early severe COVD-19 alongside increased NK cell expression of IFN-stimulated genes (ISGs) and genes involved in IFN-α signaling, while upregulation of tumor necrosis factor (TNF)-induced genes was observed in moderate diseases. NK cells exert anti-SARS-CoV-2 (severe acute respiratory syndrome coron"],"journal":["Immunity"],"pubmed_title":["Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19."],"pmcid":["PMC8416549"],"funding_grant_id":["CL-2015-01-002","SGL015\\1021","214539/Z/18/Z","ACF-2020-01-007"],"pubmed_authors":["Ludwig KU","Haniffa M","Franzenburg S","Stephenson E","Schiffer P","von Kleist M","Nattermann J","Boyke B","McHardy AC","Bitzer M","Wieczorek D","Goldman J","Hrusovsky K","Koenig PA","Keppler OT","Reusch N","Su Y","Gopel S","Sharaf ML","Landthaler M","Vogel J","Gauder M","Hubschmann D","Fischer N","Horn F","Sczyrba A","Blumert C","Walter J","Korbel J","Yuan D","Keller A","Kramer B","Ulas T","Colome-Tatche M","Kim-Hellmuth S","Nunes da Rocha U","Hanses F","Monin MB","Kohlbacher O","Scheithauer S","Schlabe S","Strassburg CP","Stegle O","Hoffmeister C","Pink I","Rieß O","Volland S","Hack G","Diefenbach A","Nischalke HD","Kuhnert D","Keitel V","Kallies R","Heath JR","Kurth I","Gabernet G","Raabe J","Kurth F","Kaiser KM","Rajewsky N","Schneider W","Nothen M","Theis F","ToVinh M","Sonnabend M","Makarewicz O","Gardner L","Overmann J","Poetsch AR","Goesmann A","Klein C","Schmidt SV","Hoeper M","Schmid-Burgk J","Janssen S","Saliba AE","Latz E","Ganzenmueller T","Sander LE","Winkler S","Bluthgen N","Singh Y","Vehreschild J","Knoll R","Heimbach A","Schultze JL","Handler K","Kummerer BM","Schmidt FI","Reynolds G","Deutsche COVID-19 OMICS Initiative (DeCOI)","Bonifacio E","Hummel M","Ralser M","Kehr B","Munchhoff M","Bezdan D","Kohrer K","Protzer U","Iftner A","Rosenstiel P","Johnson JM","Schulte EC","Stoye J","Schulte-Schrepping J","Chen D","Geißert J","Li Y","Casadei N","Kalinowski J","Grundhoff A","Ossowski S","Iftner T","Cornberg M","Rieke GJ","Hehr U","Peter S","Gagneur J","Becker M","Stubbemann P","De La Rosa Velazquez IA","Puhler A","Bartholomaus A","Frick JS","Ball AJ","Jensen B","Illig T","Ripke S","Nurnberg P","Velavan TP","Reiche K","Walker A","Hain T","Marz M","Bischoff J","Altmuller J","Clavel T","Forstner K","Grundmann H","Mertes C","Ziebuhr J","Blum H","De Domenico E","Bork P","Finnemann C","Aschenbrenner AC","Angelov A","Knop M","Pfeffer K","Bals R","Ntoumi F","Astaburuaga-Garcia R","Bonaguro L","Sawitzki B","Dilthey A","Marini F","Kremsner PG","Nahnsen S","Becker A"],"additional_accession":[]},"is_claimable":false,"name":"Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.","description":"Longitudinal analyses of the innate immune system, including the earliest time points, are essential to understand the immunopathogenesis and clinical course of coronavirus disease (COVID-19). Here, we performed a detailed characterization of natural killer (NK) cells in 205 patients (403 samples; days 2 to 41 after symptom onset) from four independent cohorts using single-cell transcriptomics and proteomics together with functional studies. We found elevated interferon (IFN)-α plasma levels in early severe COVD-19 alongside increased NK cell expression of IFN-stimulated genes (ISGs) and genes involved in IFN-α signaling, while upregulation of tumor necrosis factor (TNF)-induced genes was observed in moderate diseases. NK cells exert anti-SARS-CoV-2 (severe acute respiratory syndrome coron","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2026-05-08T00:43:42.455Z","creation":"2022-02-11T13:14:22.691Z"},"accession":"S-EPMC8416549","cross_references":{"pubmed":["34592166"],"doi":["10.1016/j.immuni.2021.09.002"]}}