biostudies-literatureUnknown12Xi S<b>Background:</b> Ciji-Hua'ai-Baosheng II Formula (CHB-II-F) is a traditional Chinese medicine formula, which specifically targets different aspects of chemotherapy-induced adverse effects in patients with cancer. In our clinical application, CHB-II-F significantly alleviated chemotherapy-induced anorexia (loss of appetite) and improved the quality of life for patients with tumor during and after chemotherapy. However, the mechanism of CHB-II-F in alleviation of chemotherapy-induced anorexia remains to be further investigated. <b>Aim of Study:</b> To explore the therapeutic effect and mechanism of CHB-II-F on chemotherapy-induced anorexia in the mice model of H₂₂ hepatoma. <b>Materials and Methods:</b> A total of 72 Kunming mice of SPF grade were inoculated subcutaneously with Frontiers in pharmacology715824https://www.ebi.ac.uk/biostudies/studies/S-EPMC8416666biostudies-literatureThe Ciji-Hua'ai-Baosheng II Formula Attenuates Chemotherapy-Induced Anorexia in Mice With H₂₂ Hepatocellular Carcinoma.PMC8416666Guo XLu DXi SGong YGao CZhao YFu BLi YHuang SZhai XWang YQian LWang ZfalseThe Ciji-Hua'ai-Baosheng II Formula Attenuates Chemotherapy-Induced Anorexia in Mice With H₂₂ Hepatocellular Carcinoma.<b>Background:</b> Ciji-Hua'ai-Baosheng II Formula (CHB-II-F) is a traditional Chinese medicine formula, which specifically targets different aspects of chemotherapy-induced adverse effects in patients with cancer. In our clinical application, CHB-II-F significantly alleviated chemotherapy-induced anorexia (loss of appetite) and improved the quality of life for patients with tumor during and after chemotherapy. However, the mechanism of CHB-II-F in alleviation of chemotherapy-induced anorexia remains to be further investigated. <b>Aim of Study:</b> To explore the therapeutic effect and mechanism of CHB-II-F on chemotherapy-induced anorexia in the mice model of H₂₂ hepatoma. <b>Materials and Methods:</b> A total of 72 Kunming mice of SPF grade were inoculated subcutaneously with 2021-01-01T00:00:00Z20212025-06-01T00:30:07.166Z2022-02-11T10:17:27.374ZS-EPMC84166663448970510.3389/fphar.2021.715824