biostudies-literatureKornej JAmerican College of Cardiology FoundationHorizon 2020 Framework ProgrammeNIA NIH HHSNHLBI NIH HHSNational Heart, Lung, and Blood InstituteHorizon 2020American Heart Association IncNational Institutes of HealthEuropean CommissionMerckH2020 Marie Skłodowska-Curie Actions1500-1507https://www.ebi.ac.uk/biostudies/studies/S-EPMC8419007biostudies-literatureUnknown18(9)<h4>Background</h4>P-wave signal-averaged electrocardiography (P-SAECG) quantifies atrial electrical activity. P-SAECG measures and their clinical correlates and heritability have had limited characterization in community-based cohorts.<h4>Objective</h4>The purpose of this study was to (1) establish reference values; (2) identify clinical risk factors associated with P-SAECG; and (3) estimate genetic heritability for P-SAECG traits.<h4>Methods</h4>We performed P-SAECG in 2 generations of Framingham Heart Study participants. We performed backward elimination regression models to assess associations of clinical factors with each SAECG trait (P-wave [PW] duration, root mean square voltage in terminal 40 ms [RMS40], terminal 30 ms RMS30, terminal 20 ms RMS20, RMS PW, and PW integral). We estimated the adjusted genetic heritability of P-SAECG measures using the Sequential Oligogenic Linkage Analysis Routines (SOLAR) program.<h4>Results</h4>We included 4307 participants (age 55 ± 14 years; 56% female). The reference values were derived from 1752 participants without cardiovascular risk factors. Median (2.5th percentile; 97.5th percentile) total PW duration was 118 ms (93; 146) in women and 128 ms (104; 158) in men in the reference sample, and 121 ms (94; 151) in women and 129 ms (103; 159) in the entire study cohort (broad sample). In the broad sample, after adjusting for age and sex, total PW duration was positively associated with height, weight, prevalent heart failure, history of atrial fibrillation (AF), and atrioventricular node blockers, and negatively associated with smoking, waist circumference, heart rate, and diabetes. The estimated heritability of P-SAECG traits was moderate, ranging from 11.9% for RMS30 to 24.9% for PW integral.<h4>Conclusion</h4>P-SAECG traits are associated with multiple AF-related risk factors and are moderately heritable.Heart rhythmP-wave signal-averaged electrocardiography: Reference values, clinical correlates, and heritability in the Framingham Heart Study.PMC84190078382592R01 HL092577HHSN268201500001C5R01HL128914-041R01AG066010R01 HL0925778477701R01 HL141434 01A1R01 AG066010R01 HL143010R01HL14301075N92019D00031R33HL144669R33 HL144669R01 HL141434HHSN268201500001IAHA_18SFRN34110082R01 HL128914N01HC251952U54HL1201618SFRN34150007U54 HL120163Soliman EZPreis SRLin HKo DMagnani JWTrinquart LKornej JBenjamin EJfalseP-wave signal-averaged electrocardiography: Reference values, clinical correlates, and heritability in the Framingham Heart Study.<h4>Background</h4>P-wave signal-averaged electrocardiography (P-SAECG) quantifies atrial electrical activity. P-SAECG measures and their clinical correlates and heritability have had limited characterization in community-based cohorts.<h4>Objective</h4>The purpose of this study was to (1) establish reference values; (2) identify clinical risk factors associated with P-SAECG; and (3) estimate genetic heritability for P-SAECG traits.<h4>Methods</h4>We performed P-SAECG in 2 generations of Framingham Heart Study participants. We performed backward elimination regression models to assess associations of clinical factors with each SAECG trait (P-wave [PW] duration, root mean square voltage in terminal 40 ms [RMS40], terminal 30 ms RMS30, terminal 20 ms RMS20, RMS PW, and PW integral). We estimated the adjusted genetic heritability of P-SAECG measures using the Sequential Oligogenic Linkage Analysis Routines (SOLAR) program.<h4>Results</h4>We included 4307 participants (age 55 ± 14 years; 56% female). The reference values were derived from 1752 participants without cardiovascular risk factors. Median (2.5th percentile; 97.5th percentile) total PW duration was 118 ms (93; 146) in women and 128 ms (104; 158) in men in the reference sample, and 121 ms (94; 151) in women and 129 ms (103; 159) in the entire study cohort (broad sample). In the broad sample, after adjusting for age and sex, total PW duration was positively associated with height, weight, prevalent heart failure, history of atrial fibrillation (AF), and atrioventricular node blockers, and negatively associated with smoking, waist circumference, heart rate, and diabetes. The estimated heritability of P-SAECG traits was moderate, ranging from 11.9% for RMS30 to 24.9% for PW integral.<h4>Conclusion</h4>P-SAECG traits are associated with multiple AF-related risk factors and are moderately heritable.2021-01-01T00:00:00Z2021 Sep2024-11-14T21:42:55.74Z2022-02-11T13:25:24.723ZS-EPMC84190073398978210.1016/j.hrthm.2021.05.009