{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Quinn MCJ"],"funding":["Scottish Randomised Trial in Ovarian Cancer","Cancer Research UK","NCATS NIH HHS","Canadian Institutes of Health 3 Research","European Community&apos;s Seventh Framework Programme","Komen Foundation for the Cure","New England-based Case-Control Study of Ovarian Cancer","Princess Margaret Cancer Centre Foundation-Bridge","Department of Defense CDMRP","Cancer Councils of New South Wales","Women&apos;s Cancer Program","Ovarian Cancer Research Fund","National Health &amp; Medical Research Council of Australia","Imperial Experimental Cancer Research Centre","Canadian Institutes of Health Research","General Clinical Research Center","U.S. Army Medical Research and Materiel Command","Australian National Health and Medical Research Council Enabling Grants","U.S. National Institutes of Health 2","Ovarian Cancer Prognosis and Lifestyle Study","US Army Medical Research and Materiel Command","National Center for Advancing Translational Sciences","ELAN Funds of the University of Erlangen-Nuremberg","Nationaal Kankerplan","National Center for Research Resources","NCRR NIH HHS","Princess Margaret Cancer Centre","Post-Cancer GWAS initiative","NIH","Department of Defense","North Carolina Ovarian Cancer Study","National Health and Medical Research Council of Australia","American Cancer Society Early Detection Professorship","Breast Cancer Research Foundation","Haukeland University Hospital","innesota Ovarian Cancer Alliance","University of Bergen","Mayo Foundation","NCI","Mayo Clinic Ovarian Cancer Case-Control Study","University of Sydney Cancer Research Fund","CIHR Team in Familial Risks of Breast Cancer","NCI NIH HHS","National Health and Medical Research Council","Mayo Clinic Case-Only Ovarian Cancer Study","Gynaecological Oncology Biobank at Westmead","Department of Defence"],"pagination":["1669-1680"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8419101"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(9)"],"pubmed_abstract":["<h4>Background</h4>Many loci have been found to be associated with risk of epithelial ovarian cancer (EOC). However, although there is considerable variation in progression-free survival (PFS), no loci have been found to be associated with outcome at genome-wide levels of significance.<h4>Methods</h4>We carried out a genome-wide association study (GWAS) of PFS in 2,352 women with EOC who had undergone cytoreductive surgery and standard carboplatin/paclitaxel chemotherapy.<h4>Results</h4>We found seven SNPs at 12q24.33 associated with PFS (<i>P</i> < 5 × 10<sup>-8</sup>), the top SNP being rs10794418 (HR = 1.24; 95% CI, 1.15-1.34; <i>P</i> = 1.47 × 10<sup>-8</sup>). High expression of a nearby gene, <i>ULK1</i>, is associated with shorter PFS in EOC, and with poor prognosis in other cancers"],"journal":["Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology"],"pubmed_title":["Identification of a Locus Near &lt;i&gt;ULK1&lt;/i&gt; Associated With Progression-Free Survival in Ovarian Cancer."],"pmcid":["PMC8419101"],"funding_grant_id":["DAMD17-02-1-0666","628903","400281","C5047/A10692","R01 CA 054419-10","P50 CA159981","UL1 TR001881","DAMD17-02-1-0669","U19 CA148537","C12292/A11174","C1287/A10118","R01-CA149429","C1281/A12014","R01 CA054419","P50-CA159981","R01 CA149429","1113867","R01 CA128978","P50 CA105009","U19 CA148065","C536/A6689","R01- CA61107","R01-CA58598","16561","N01-PC-67001","R01 CA076016","PI 12/01319","UL1 TR000124","P50-CA136393","R01 CA126841","15/RIG/1-16","C1312/A15589","P30-CA15083","W81XWH-10-1-0341","P50 CA136393","P30 CA015083","1U19 CA148112","HEALTH-F2-2009-223175","APP1120431","R01-CA126841","K07-CA80668","R01-CA122443","SIOP-06-258-01-COUN","P30 CA008748","K07 CA080668","N01-CN-55424","R01-CA058598","CA1×01HG007491-01","C8197/A16565","R01 CA122443","R01 CA248288","APP1025142","223175","120950-SIOP-06-258-06-COUN","R01 CA058598","94 222 52","M01 RR000056","1U19 CA148065,","R01 CA095023","199600","1U19 CA148537","UL1TR000124","ULTR000445","12/RIG/1-17","C1287/A 10710","310670","C536/A13086","W81XWH-10-1-0280","C5047/A8384","U19-CA148112","MO1- RR000056","DAMD17-01-1-0729","U19 CA148112","CA128978","APP1158083","R01CA095023","C5047/A15007","R01-CA76016"],"pubmed_authors":["Heitz F","Gao B","Dork T","Kennedy CJ","Lu Y","Webb PM","Shi W","Hinsley S","Patch AM","Pharoah PDP","for Australian Ovarian Cancer Study Group","Hogdall CK","Glubb DM","Larson MC","Winham SJ","Gharahkhani P","Bjorge L","Woo M","Chenevix-Trench G","McCue K","Johnatty SE","Fereday S","Quinn MCJ","Moffitt M","Ong JS","Fasching PA","Lester J","Ene GEV","MacGregor S","Beesley J","Modugno F","O'Mara TA","Carney ME","Kjaer SK","Berchuck A","Karlan BY","Velez Edwards DR","Civitarese A","Terry KL","Tyrer JP","Edwards SL","Pejovic T","Jensen A","Bauman K","deFazio A","Benitez J","May T","Beckmann MW","Cunningham JM","Moysich K","Schildkraut JM","Huntsman DG","AGO Study Group","OPAL Study Group","Durst M","Cramer DW","Vergote I","Riggan MJ","Garcia MJ","Pfisterer J","Armasu SM","Goodman MT","Glasspool R","Lambrechts D","Hogdall E","Friedlander M","Beeghly-Fadiel A","McCauley BM","du Bois A","Goode EL"],"additional_accession":[]},"is_claimable":false,"name":"Identification of a Locus Near &lt;i&gt;ULK1&lt;/i&gt; Associated With Progression-Free Survival in Ovarian Cancer.","description":"<h4>Background</h4>Many loci have been found to be associated with risk of epithelial ovarian cancer (EOC). However, although there is considerable variation in progression-free survival (PFS), no loci have been found to be associated with outcome at genome-wide levels of significance.<h4>Methods</h4>We carried out a genome-wide association study (GWAS) of PFS in 2,352 women with EOC who had undergone cytoreductive surgery and standard carboplatin/paclitaxel chemotherapy.<h4>Results</h4>We found seven SNPs at 12q24.33 associated with PFS (<i>P</i> < 5 × 10<sup>-8</sup>), the top SNP being rs10794418 (HR = 1.24; 95% CI, 1.15-1.34; <i>P</i> = 1.47 × 10<sup>-8</sup>). High expression of a nearby gene, <i>ULK1</i>, is associated with shorter PFS in EOC, and with poor prognosis in other cancers","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2026-04-08T18:22:21.336Z","creation":"2026-04-08T09:10:46.793Z"},"accession":"S-EPMC8419101","cross_references":{"pubmed":["34162658"],"doi":["10.1158/1055-9965.EPI-20-1817","10.1158/1055-9965.epi-20-1817"]}}