biostudies-literatureZhang Hthe National Key Research and Development Program of ChinaNational Natural Science Foundation of ChinaScience and Technology Project of Tianjin Municipal Health CommissionClinical Trial Project of Tianjin Medical UniversityBethune Charitable Foundation-Excelsior Surgical Fund6149-6164https://www.ebi.ac.uk/biostudies/studies/S-EPMC8419772biostudies-literatureUnknown10(17)<h4>Background</h4>The purpose of this study was to assess the prognostic performance of the log odds of positive lymph nodes (LODDS) value compared with the pathological N stage and lymph node ratio (LNR) in patients with esophageal squamous cell carcinoma (ESCC).<h4>Method</h4>In total 1144 patients diagnosed with ESCC from the Surveillance, Epidemiology, and End Results (SEER) database and 930 patients from our validation cohort were eligible. Kaplan-Meier plotter and multivariate Cox proportional hazards models were conducted to investigate the prognostic value of the N stage, LNR stage, and LODDS stage. The homogeneity, discriminatory ability, and monotonicity of these variables were evaluated using the linear trend χ² test, likelihood ratio χ² test, Akaike inforCancer medicineThe prognostic performance of the log odds of positive lymph nodes in patients with esophageal squamous cell carcinoma: A population study of the US SEER database and a Chinese single-institution cohort.PMC84197722016YFC09014012017kylc00682002551HZB-20190528-1881772619KJ20119Yang YZhang HZhu KJia RTang PRen PXiao WGong LYu ZfalseThe prognostic performance of the log odds of positive lymph nodes in patients with esophageal squamous cell carcinoma: A population study of the US SEER database and a Chinese single-institution cohort.<h4>Background</h4>The purpose of this study was to assess the prognostic performance of the log odds of positive lymph nodes (LODDS) value compared with the pathological N stage and lymph node ratio (LNR) in patients with esophageal squamous cell carcinoma (ESCC).<h4>Method</h4>In total 1144 patients diagnosed with ESCC from the Surveillance, Epidemiology, and End Results (SEER) database and 930 patients from our validation cohort were eligible. Kaplan-Meier plotter and multivariate Cox proportional hazards models were conducted to investigate the prognostic value of the N stage, LNR stage, and LODDS stage. The homogeneity, discriminatory ability, and monotonicity of these variables were evaluated using the linear trend χ² test, likelihood ratio χ² test, Akaike infor2021-01-01T00:00:00Z2021 Sep2025-04-22T20:49:13.097Z2022-02-11T10:48:08.511ZS-EPMC84197723424081210.1002/cam4.4120