biostudies-literatureUnknown10(8)Cui WS<h4>Background</h4>To evaluate the efficacy and safety of aildenafil citrate in the treatment of erectile dysfunction (ED) in Chinese population.<h4>Methods</h4>A multicenter, randomized, double-blind, placebo-controlled, double-cycle crossover trial was conducted in three medical centers. Male patients with mild to moderate ED were randomized into two groups and received either aildenafil citrate or placebos, followed by a crossover administration after a 7-day washout. The primary outcome was the duration of penile rigidity over 60% measured by RigiScan^® Plus. Main secondary outcomes were the duration of penile rigidity over 80% and erectile hardness score (EHS).<h4>Results</h4>A total of 60 patients with mild to moderate ED were enrolled in the study and 57 of them completed Translational andrology and urology3358-3367https://www.ebi.ac.uk/biostudies/studies/S-EPMC8421832biostudies-literatureEfficacy and safety of aildenafil citrate in Chinese men with erectile dysfunction: a multicenter, randomized, double-blind, placebo-controlled crossover trial.PMC8421832Cui WSLei HETian LGuan RLWang TZhu SNXin ZCYao CLiu JHFeng YHWang JfalseEfficacy and safety of aildenafil citrate in Chinese men with erectile dysfunction: a multicenter, randomized, double-blind, placebo-controlled crossover trial.<h4>Background</h4>To evaluate the efficacy and safety of aildenafil citrate in the treatment of erectile dysfunction (ED) in Chinese population.<h4>Methods</h4>A multicenter, randomized, double-blind, placebo-controlled, double-cycle crossover trial was conducted in three medical centers. Male patients with mild to moderate ED were randomized into two groups and received either aildenafil citrate or placebos, followed by a crossover administration after a 7-day washout. The primary outcome was the duration of penile rigidity over 60% measured by RigiScan^® Plus. Main secondary outcomes were the duration of penile rigidity over 80% and erectile hardness score (EHS).<h4>Results</h4>A total of 60 patients with mild to moderate ED were enrolled in the study and 57 of them completed 2021-01-01T00:00:00Z2021 Aug2025-04-04T09:36:55.412Z2025-04-04T09:36:55.412ZS-EPMC84218323453226010.21037/tau-21-441