{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shaw AE"],"funding":["Medical Research Council","Wellcome Trust"],"pagination":["e3001352"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8423302"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(9)"],"pubmed_abstract":["Antiviral defenses can sense viral RNAs and mediate their destruction. This presents a challenge for host cells since they must destroy viral RNAs while sparing the host mRNAs that encode antiviral effectors. Here, we show that highly upregulated interferon-stimulated genes (ISGs), which encode antiviral proteins, have distinctive nucleotide compositions. We propose that self-targeting by antiviral effectors has selected for ISG transcripts that occupy a less self-targeted sequence space. Following interferon (IFN) stimulation, the CpG-targeting antiviral effector zinc-finger antiviral protein (ZAP) reduces the mRNA abundance of multiple host transcripts, providing a mechanistic explanation for the repression of many (but not all) interferon-repressed genes (IRGs). Notably, IRGs tend to be"],"journal":["PLoS biology"],"pubmed_title":["The antiviral state has shaped the CpG composition of the vertebrate interferome to avoid self-targeting."],"pmcid":["PMC8423302"],"funding_grant_id":["MR/K024752/1","MR/R021562/1","201366/Z/16/Z","MC_UU_12014/10","MC_UU_12014/8","MC_UU_12014/12","MR/P022642/1","217221/Z/19/Z"],"pubmed_authors":["Da Silva AF","Stewart DG","Wickenhagen A","Busby J","Palmarini M","Mollentze N","Robertson DL","Orton RJ","Turnbull ML","Rihn SJ","Johnson PCD","Collados MR","Shaw AE","Kuchi S","Castello A","Streicker DG","Wilson SJ","Sugrue E","Smollett K","Gu Q","Bamford CGG","Bakshi S"],"additional_accession":[]},"is_claimable":false,"name":"The antiviral state has shaped the CpG composition of the vertebrate interferome to avoid self-targeting.","description":"Antiviral defenses can sense viral RNAs and mediate their destruction. This presents a challenge for host cells since they must destroy viral RNAs while sparing the host mRNAs that encode antiviral effectors. Here, we show that highly upregulated interferon-stimulated genes (ISGs), which encode antiviral proteins, have distinctive nucleotide compositions. We propose that self-targeting by antiviral effectors has selected for ISG transcripts that occupy a less self-targeted sequence space. Following interferon (IFN) stimulation, the CpG-targeting antiviral effector zinc-finger antiviral protein (ZAP) reduces the mRNA abundance of multiple host transcripts, providing a mechanistic explanation for the repression of many (but not all) interferon-repressed genes (IRGs). Notably, IRGs tend to be","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2026-04-08T08:25:43.57Z","creation":"2022-02-11T10:50:23.166Z"},"accession":"S-EPMC8423302","cross_references":{"pubmed":["34491982"],"doi":["10.1371/journal.pbio.3001352"]}}