{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Thomas NJ"],"funding":["NIDDK NIH HHS","Medical Research Council","Diabetes UK","National Institute for Health Research (NIHR)","Wellcome Trust"],"pagination":["2258-2265"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8423681"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["64(10)"],"pubmed_abstract":["Aims/hypothesis
Among white European children developing type 1 diabetes, the otherwise common HLA haplotype DR15-DQ6 is rare, and highly protective. Adult-onset type 1 diabetes is now known to represent more overall cases than childhood onset, but it is not known whether DR15-DQ6 is protective in older-adult-onset type 1 diabetes. We sought to quantify DR15-DQ6 protection against type 1 diabetes as age of onset increased.Methods
In two independent cohorts we assessed the proportion of type 1 diabetes cases presenting through the first 50 years of life with DR15-DQ6, compared with population controls. In the After Diabetes Diagnosis Research Support System-2 (ADDRESS-2) cohort (n = 1458) clinician-diagnosed type 1 diabetes was confirmed by positivity for one or more islet-s"],"journal":["Diabetologia"],"pubmed_title":["DR15-DQ6 remains dominantly protective against type 1 diabetes throughout the first five decades of life."],"pmcid":["PMC8423681"],"funding_grant_id":["MC_PC_17228","17/0005757","220601/Z/20/Z","219606/Z/19/Z","16/0005529","MC_QA137853","U01 DK127382","WT097835MF"],"pubmed_authors":["Patel KA","Hagopian WA","Oliver NS","Weedon MN","Thomas NJ","Johnston DG","Dennis JM","Walkey HC","Sharp SA","Kaur A","Oram RA","Misra S"],"additional_accession":[]},"is_claimable":false,"name":"DR15-DQ6 remains dominantly protective against type 1 diabetes throughout the first five decades of life.","description":"Aims/hypothesis
Among white European children developing type 1 diabetes, the otherwise common HLA haplotype DR15-DQ6 is rare, and highly protective. Adult-onset type 1 diabetes is now known to represent more overall cases than childhood onset, but it is not known whether DR15-DQ6 is protective in older-adult-onset type 1 diabetes. We sought to quantify DR15-DQ6 protection against type 1 diabetes as age of onset increased.Methods
In two independent cohorts we assessed the proportion of type 1 diabetes cases presenting through the first 50 years of life with DR15-DQ6, compared with population controls. In the After Diabetes Diagnosis Research Support System-2 (ADDRESS-2) cohort (n = 1458) clinician-diagnosed type 1 diabetes was confirmed by positivity for one or more islet-s","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2026-05-09T07:19:00.033Z","creation":"2022-02-11T12:29:34.645Z"},"accession":"S-EPMC8423681","cross_references":{"pubmed":["34272580"],"doi":["10.1007/s00125-021-05513-4"]}}