{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["van der Merwe Y"],"funding":["NEI NIH HHS"],"pagination":["1339-1359"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8423893"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(2)"],"pubmed_abstract":["Glaucoma is a neurodegenerative disease that causes progressive, irreversible vision loss. Currently, intraocular pressure (IOP) is the only modifiable risk factor for glaucoma. However, glaucomatous degeneration may continue despite adequate IOP control. Therefore, there exists a need for treatment that protects the visual system, independent of IOP. This study sought, first, to longitudinally examine the neurobehavioral effects of different magnitudes and durations of IOP elevation using multi-parametric magnetic resonance imaging (MRI), optokinetics and histology; and, second, to evaluate the effects of oral citicoline treatment as a neurotherapeutic in experimental glaucoma. Eighty-two adult Long Evans rats were divided into six groups: acute (mild or severe) IOP elevation, chronic (ci"],"journal":["Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics"],"pubmed_title":["Citicoline Modulates Glaucomatous Neurodegeneration Through Intraocular Pressure-Independent Control."],"pmcid":["PMC8423893"],"funding_grant_id":["R01 EY028125"],"pubmed_authors":["Leung CK","Faiq MA","Chan KC","Wollstein G","van der Merwe Y","Ho LC","Murphy MC","Sims JR","Yang XL","Conner IP","Yu Y","Schuman JS"],"additional_accession":[]},"is_claimable":false,"name":"Citicoline Modulates Glaucomatous Neurodegeneration Through Intraocular Pressure-Independent Control.","description":"Glaucoma is a neurodegenerative disease that causes progressive, irreversible vision loss. Currently, intraocular pressure (IOP) is the only modifiable risk factor for glaucoma. However, glaucomatous degeneration may continue despite adequate IOP control. Therefore, there exists a need for treatment that protects the visual system, independent of IOP. This study sought, first, to longitudinally examine the neurobehavioral effects of different magnitudes and durations of IOP elevation using multi-parametric magnetic resonance imaging (MRI), optokinetics and histology; and, second, to evaluate the effects of oral citicoline treatment as a neurotherapeutic in experimental glaucoma. Eighty-two adult Long Evans rats were divided into six groups: acute (mild or severe) IOP elevation, chronic (ci","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-22T09:14:22.957Z","creation":"2025-04-05T22:59:00.865Z"},"accession":"S-EPMC8423893","cross_references":{"pubmed":["33846961"],"doi":["10.1007/s13311-021-01033-6"]}}