{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Muller CR"],"funding":["NHLBI NIH HHS"],"pagination":["1226-1234"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8424550"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["130(4)"],"pubmed_abstract":["Easy access to high-calorie and fat-dense fast food has resulted in unhealthy dietary and lifestyle changes worldwide, which affects both developed and developing economies. This predisposes populations to a considerable number of metabolic and inflammatory conditions, such as diabetes, nonalcoholic fatty liver disease (NAFLD), and cardiovascular disease (CVD). Guinea pigs have been proposed as a model to study high-fat diet-induced metabolic disease due to their similar antioxidant metabolism and lipid profile to humans, and their susceptibility to atherosclerosis and endothelial disease. This study aims to evaluate cardiovascular and metabolic disorders induced by high-fat high-sucrose diet (HFHSD) in guinea pigs. Two to three-week-old male guinea pigs were fed a normal diet (ND) or HFHS"],"journal":["Journal of applied physiology (Bethesda, Md. : 1985)"],"pubmed_title":["High fat high sucrose diet-induced dyslipidemia in guinea pigs."],"pmcid":["PMC8424550"],"funding_grant_id":["R01 HL138116","R01 HL126945"],"pubmed_authors":["Cabrales P","Muller CR","Eaker AM","Dos Santos F","Williams AT","Palmer AF"],"additional_accession":[]},"is_claimable":false,"name":"High fat high sucrose diet-induced dyslipidemia in guinea pigs.","description":"Easy access to high-calorie and fat-dense fast food has resulted in unhealthy dietary and lifestyle changes worldwide, which affects both developed and developing economies. This predisposes populations to a considerable number of metabolic and inflammatory conditions, such as diabetes, nonalcoholic fatty liver disease (NAFLD), and cardiovascular disease (CVD). Guinea pigs have been proposed as a model to study high-fat diet-induced metabolic disease due to their similar antioxidant metabolism and lipid profile to humans, and their susceptibility to atherosclerosis and endothelial disease. This study aims to evaluate cardiovascular and metabolic disorders induced by high-fat high-sucrose diet (HFHSD) in guinea pigs. Two to three-week-old male guinea pigs were fed a normal diet (ND) or HFHS","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-26T13:02:08.49Z","creation":"2025-04-06T14:08:35.859Z"},"accession":"S-EPMC8424550","cross_references":{"pubmed":["33703947"],"doi":["10.1152/japplphysiol.00013.2021"]}}