biostudies-literatureUnknown12Aboualigalehdari E<h4>Background</h4>Biofilm is an accumulation of cells, which are formed on mucosal surfaces of the host as well as on medical devices. The inherent resistance of <i>Candida</i> strains producing biofilms to antimicrobial agents is an important and key feature for biofilm growth, which can lead to treatment failure. This resistance is due to the regulatory increase of the output pumps, the presence of extracellular matrix, and the existence of persister cells. Persister cells are phenotypic variants that have MICs similar to antibiotic-sensitive populations and are able to tolerate high doses of antibiotics. The current study investigated the possible role of <i>EFG1, BCR1</i>, and <i>CAT1</i> in the establishment or maintenance of persister cells in <i>Candida albicans</i> strains that prFrontiers in microbiology651221https://www.ebi.ac.uk/biostudies/studies/S-EPMC8425484biostudies-literatureTranscription Factors of CAT1, EFG1, and BCR1 Are Effective in Persister Cells of <i>Candida albicans</i>-Associated HIV-Positive and Chemotherapy Patients.PMC8425484Tahmasebi Birgani MAboualigalehdari EFatahinia MHosseinzadeh MfalseTranscription Factors of CAT1, EFG1, and BCR1 Are Effective in Persister Cells of <i>Candida albicans</i>-Associated HIV-Positive and Chemotherapy Patients.<h4>Background</h4>Biofilm is an accumulation of cells, which are formed on mucosal surfaces of the host as well as on medical devices. The inherent resistance of <i>Candida</i> strains producing biofilms to antimicrobial agents is an important and key feature for biofilm growth, which can lead to treatment failure. This resistance is due to the regulatory increase of the output pumps, the presence of extracellular matrix, and the existence of persister cells. Persister cells are phenotypic variants that have MICs similar to antibiotic-sensitive populations and are able to tolerate high doses of antibiotics. The current study investigated the possible role of <i>EFG1, BCR1</i>, and <i>CAT1</i> in the establishment or maintenance of persister cells in <i>Candida albicans</i> strains that pr2021-01-01T00:00:00Z20212026-05-07T23:41:42.314Z2022-02-11T10:57:57.344ZS-EPMC84254843451256210.3389/fmicb.2021.651221